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Preparation of CL-20 with Controllable Particle Size Using Microfluidic Technology.
Molecules
March 2025
Xi'an Modern Chemistry Research Institute, Xi'an 710065, China.
As a typical high-energy-density material, the sensitivity of CL-20 severely limits its application in explosives and propellants. Adjusting its structure at the microscopic level can effectively solve such problems. In this study, a microfluidic recrystallization technique was used to prepare ε-CL-20 with three different particle sizes, with narrow particle size distributions (D = 2.
View Article and Find Full Text PDFSpherical Amides with Symmetry: Improved Synthetic Approach and Structural/Optical Analysis.
Molecules
February 2025
Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi 274-8510, Chiba, Japan.
A spherical amide with symmetry was synthesized by a one-step cyclization reaction using triphenylphosphine and hexachloroethane as coupling reagents. This method enabled synthesis of -benzyl and -allyl derivatives, which could not be obtained by the previously reported method. The optical resolution of each compound was measured, and their electronic circular dichroism spectra revealed that they were mirror images.
View Article and Find Full Text PDFEstimation and Hypothesis Testing of Strain-Specific Vaccine Efficacy With Missing Strain Types With Application to a COVID-19 Vaccine Trial.
Stat Med
March 2025
Vaccine and Infectious Disease and Public Health Sciences Divisions, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Based on data from a randomized, controlled vaccine efficacy trial, this article develops statistical methods for assessing vaccine efficacy (VE) to prevent COVID-19 infections by a discrete set of genetic strains of SARS-CoV-2. Strain-specific VE adjusting for possibly time-varying covariates is estimated using augmented inverse probability weighting to address missing viral genotypes under a competing risks model that allows separate baseline hazards for different risk groups. Hypothesis tests are developed to assess whether the vaccine provides at least a specified level of VE against some viral genotypes and whether VE varies across genotypes.
View Article and Find Full Text PDFSynthesis and Crystal Structures of β -Diketonato Associated Aluminium Complexes as Potential Catalysts for the Ring-Opening Polymerization of ε-Caprolactone.
Chempluschem
March 2025
Vellore Institute of Technology, Chemistry, vellore, 632014, vellore, INDIA.
A couple of novel crystalline aluminium(III) derivatives containing tridentate Schiff base ligand (HL) and β-diketones (acetylacetone = acac, benzoylacetone = bnzac, dibenzoylmethane = dbnz) viz [Al(L)bnzac] [Al1], [Al(L)dnbz] [Al2] and [Al(L)acac] [Al3] were synthesized and characterized well using different spectroscopic techniques and elemental analysis. Single crystal X-ray diffraction (SCXRD) analysis of Al2 & Al3 exhibited hexacoordinated geometry around aluminium centre atom. The ring opening polymerization (ROP) of caprolactone (CL) was evaluated to determine the catalytic potential of the complexes Al1-Al3 in absence as well as in presence of benzyl alcohol.
View Article and Find Full Text PDFNeurophysiological correlates of subjective cognitive decline in perimenopausal and postmenopausal midlife women at risk for Alzheimer's disease.
Menopause
March 2025
Department of Radiology, Weill Cornell Medicine, New York, NY.
Objective: This study aimed to investigate neurophysiological correlates of subjective cognitive decline (SCD) among midlife women at risk for Alzheimer's disease (AD).
Methods: We examined 156 cognitively normal perimenopausal and postmenopausal women aged 40 to 65 years, with an AD family history and/or apolipoprotein E epsilon 4 genotype, who were not on menopause hormone therapy. Participants underwent neuropsychological testing, health and menopausal symptom questionnaires, and brain volumetric magnetic resonance imaging, arterial spin labeling-magnetic resonance (MR) measuring cerebral blood flow, and 31phosphorus magnetic resonance spectroscopy (31P-MRS) measuring mitochondria high-energy phosphates (adenosine triphosphate [ATP], phosphocreatine [PCr], inorganic phosphate [Pi]).
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