Several heterocyclic ketones were investigated as potential inhibitors of histone deacetylase. Nanomolar inhibitors such as 22 and 25 were obtained, the anti-proliferative activity of which were shown to be mediated by HDAC inhibition.
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| http://dx.doi.org/10.1016/j.bmcl.2003.09.007 | DOI Listing |
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