Yeast cells have an asymmetric, stem-cell-like division. As the mother cell ages it becomes 100 times more genetically unstable, but it is only the daughter cells that exhibit loss of heterozygosity; the latter effect is not connected to SIR2-dependent aging, but seems to be accompanied by a loss of the DNA damage checkpoint.
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| http://dx.doi.org/10.1016/j.cub.2003.10.018 | DOI Listing |
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