Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.

Yong-Jin Wu Huan He Shuanghua Hu Yazhong Huang Paul M Scola Katharine Grant-Young Robert L Bertekap Dedong Wu Qi Gao Yi Li Cheryl Klakouski Ryan S Westphal

J Med Chem

Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.

Published: November 2003

(E)-3-(Benzenesulfonyl)-2-(methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine (7) was found to be a potent and selective 5-HT(6) antagonist. A one-step synthesis of this compound is described.

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http://dx.doi.org/10.1021/jm034142q	DOI Listing

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