CLA is a generic term describing different isomers of linoleic acid with two conjugated double bonds. Various metabolic effects have been demonstrated following administration of CLA, including a change in body composition in animals. However, the effects of pure CLA isomers are not fully understood. In addition, conjugated octadecatrienoic acids such as calendic acid have not been extensively investigated. In this study, male and female ICR mice were fed pure CLA isomers (cis9,trans11 or trans10,cis12) or calendic acid (trans8,trans10,cis12) as their ethyl esters for 6 wk. Body protein content was significantly increased after feeding CLA isomers, either as pure isomers or as a mixture. Calendic acid significantly decreased body fat content in males. CLA (pure isomers or a mixture) significantly decreased body fat in both males and females, with the trans10,cis12 isomer being the most effective. The effect of the cis9,trans11 isomer was more pronounced in females than in males. It was concluded that the trans10,cis12 CLA isomer was mainly responsible for the decrease in fat content in mice, without a significant modification of feed efficiency, and that it was more effective than calendic acid.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11745-003-1142-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Heterologous Production of Calendic Acid Naturally Found in by Recombinant Fission Yeast.
J Agric Food Chem
March 2023
Institute of Animal Biochemistry and Genetics, Centre of Biosciences, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava 84005, Slovakia.
Calendic acid (CA) is a conjugated fatty acid with anti-cancer properties that is widely present in seed oil of . Using the co-expression of fatty acid conjugases (CoFADX-1 or CoFADX-2) and fatty acid desaturase (PgFAD2), we metabolically engineered the synthesis of CA in the yeast without the need for linoleic acid (LA) supplementation. The highest CA titer and achieved accumulation were 4.
View Article and Find Full Text PDFConjugated Linolenic Acids: Implication in Cancer.
J Agric Food Chem
June 2019
Molecular Genetics Lab, Amity Institute of Biotechnology , Amity University Uttar Pradesh, Noida - 201303 , India.
Conjugated fatty acids (CFAs) including both conjugated linoleic acids (CLAs) and conjugated linolenic acids (CLNAs) have various health promoting effects. These beneficial effects are comprised by their antioxidant, antiatherogenecity, anticarcinogenic activities, etc. Several reports indicate that CLNAs such as eleostearic acid, punicic acid, jacaric acid, and calendic acid possess anticancer properties.
View Article and Find Full Text PDFRobust inhibitory effects of conjugated linolenic acids on a cyclooxygenase-related linoleate 10S-dioxygenase: Comparison with COX-1 and COX-2.
Biochim Biophys Acta
October 2015
Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:
There are many reports of the anti-inflammatory, anti-cancer, and anti-atherosclerotic activities of conjugated linolenic acids (cLNA). They constitute a small percentage of fatty acids in the typical human diet, although up to 80% of the fatty acids in certain fruits such as pomegranate. In the course of studying a bacterial fatty acid dioxygenase (Nostoc linoleate 10S-DOX, an ancient relative of mammalian cyclooxygenases), we detected strong inhibitory activity in a commercial sample of linoleic acid.
View Article and Find Full Text PDFInduction of apoptosis and inhibition of invasion in choriocarcinoma JEG-3 cells by α-calendic acid and β-calendic acid.
Prostaglandins Leukot Essent Fatty Acids
October 2013
Liaoning Key Laboratory of Food Biological Technology, School of Food Science and Technology, Dalian Polytechnic University, No. 1 Qinggongyuan, Gan District, Dalian 116034, China.
Alfa-calendic acid and β-calendic acid, geometric and positional isomers of linolenic acid were previously shown to possess potent anticancer properties. In this study, we found that α-calendic acid and β-calendic acid could induce apoptosis and suppress invasion of human choriocarcinoma JEG-3 cells in vitro. Treatment with α-calendic acid and β-calendic acid significantly increased oxidative stress in human choriocarcinoma JEG-3 cells detected by the level of reactive oxygen species (ROS), lipid peroxidation production malondialdehyde (MDA), glutathione (GSH) and the effects of antioxidants NAC and α-tocopherol.
View Article and Find Full Text PDFFatty acid composition of lipids in pot marigold (Calendula officinalis L.) seed genotypes.
Chem Cent J
January 2013
University of Agricultural Sciences and Veterinary Medicine, Manastur 3-5, Cluj-Napoca, 400372, Romania.
Background: Calendula officinalis L. (pot marigold) is an annual aromatic herb with yellow or golden-orange flowers, native to the Mediterranean climate areas. Their seeds contain significant amounts of oil (around 20%), of which about 60% is calendic acid.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!