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Genome-wide association studies (GWAS) have identified genetic variants robustly associated with asthma. A potential near-term clinical application is to calculate polygenic risk score (PRS) to improve disease risk prediction. The value of PRS, as part of numerous multi-source variables used to define asthma, remains unclear.
View Article and Find Full Text PDFA novel breath pattern model and analysis to minimize patient discomfort in medical ventilators.
Sci Rep
January 2025
Department of Mechanical Engineering, PSG Institute of Technology and Applied Research, Coimbatore, 641026, India.
Typical waveforms used for the simulation of pressure and volume-controlled ventilation in medical ventilators have been extensively studied in the literature. The majority of simulation studies reported employ the step pattern or ramp pattern to model the pressure and flow variations in pressure/volume-controlled ventilation. It was observed that the above waveforms tend to add to the discomfort level of patients due to the presence of jerks in derivatives of pressure/flow variations; the pressure/flow variation of air and oxygen mixture should be smooth so that the patient discomfort is kept at a minimal level.
View Article and Find Full Text PDFRecent Advances and New Therapeutic Goals in the Management of Severe Asthma.
Intern Med
January 2025
Division of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, Japan.
Asthma is characterized by chronic airway inflammation as its primary pathological condition, which leads to various respiratory symptoms due to airway narrowing, with type 2 inflammation playing a central role. Asthma treatment, primarily centered on inhaled corticosteroids, aims to suppress type 2 inflammation and improve airway narrowing. However, severe asthma that cannot be controlled with high-dose inhaled corticosteroids or other asthma medications remains a clinical issue.
View Article and Find Full Text PDFClinical and epidemiological characteristics and outcomes of patients affected by COVID-19 in the Intensive Care Unit.
Rev Bras Enferm
January 2025
Universidade Federal de Santa Catarina. Florianópolis, Santa Catarina, Brazil.
Objective: To understand the clinical and epidemiological characteristics, outcomes, and nursing care of adult patients affected by COVID-19 in the Intensive Care Unit.
Methods: This is a quantitative, retrospective, and descriptive study. The study participants were clinical and epidemiological statistical reports.
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