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Unlocking Glioblastoma Secrets: Natural Killer Cell Therapy against Cancer Stem Cells.
Cancers (Basel)
December 2023
Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN 47405, USA.
Glioblastoma (GBM) represents a paramount challenge as the most formidable primary brain tumor characterized by its rapid growth, aggressive invasiveness, and remarkable heterogeneity, collectively impeding effective therapeutic interventions. The cancer stem cells within GBM, GBM stem cells (GSCs), hold pivotal significance in fueling tumor advancement, therapeutic refractoriness, and relapse. Given their unique attributes encompassing self-renewal, multipotent differentiation potential, and intricate interplay with the tumor microenvironment, targeting GSCs emerges as a critical strategy for innovative GBM treatments.
View Article and Find Full Text PDFAnti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects.
Vet Sci
January 2023
Avian and Rabbit Diseases Department, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32897, Egypt.
Chronic stress is recognized as a secret killer in poultry. It is associated with systemic inflammation due to cytokine release, dysbiosis, and the so-called leaky gut syndrome, which mainly results from oxidative stress reactions that damage the barrier function of the cells lining the gut wall. Poultry, especially the genetically selected broiler breeds, frequently suffer from these chronic stress symptoms when exposed to multiple stressors in their growing environments.
View Article and Find Full Text PDFRole of NKT cells in cancer immunotherapy-from bench to bed.
Med Oncol
December 2022
Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Natural killer T (NKT) cells are a specific T cell subset known to express the αβ-T cell receptor (TCR) for antigens identification and express typical NK cell specifications, such as surface expression of CD56 and CD16 markers as well as production of granzyme. Human NKT cells are divided into two subgroups based on their cytokine receptor and TCR repertoire. Both of them are CD1-restricted and recognize lipid antigens presented by CD1d molecules.
View Article and Find Full Text PDFAnti-Ro/SSA and/or anti-La/SSB antibodies are associated with adverse endometrial status.
Am J Reprod Immunol
June 2023
Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Article Synopsis
- - The presence of anti-Ro/SSA and/or anti-La/SSB antibodies negatively impacts pregnancy outcomes, but their effect on endometrial immune status is still not fully understood.
- - Researchers collected menstrual blood samples from women with and without these antibodies to analyze variations in immune cell types, particularly focused on natural killer (NK) cells and T cells.
- - Findings revealed that women with the antibodies exhibited a different immune cell composition in their menstrual blood, specifically more exhausted NK cells and heightened activity of CD8+ T cells, which may disrupt the uterine environment and lead to poor pregnancy results.
Nutraceuticals to Mitigate the Secret Killers in Animals.
Vet Sci
August 2022
Avian and Rabbit Diseases Department, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32897, Egypt.
In the past few years, the concept of "gut health" has established itself as a norm in the scientific literature and animal production [...
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