Most textbook treatments imply, and almost all theoretical analyses assume, that mutualistic interactions take place between a single pair of interacting partner species. A major goal of this symposium is to broaden and shift this pairwise perspective and make it concordant with the emerging view that locally exclusive mutualisms between just two species are the exception and that many communities include guilds of mutualistic species on one or both sides of the interaction. Many pollination and seed-dispersal mutualisms have long been recognized as diffuse, but recent molecular analyses are revealing unrecognized partner diversity in mutualistic interactions previously thought to be locally species specific. Co-occurring species within a mutualist guild are unlikely to be ecologically equivalent in the way they locate, compete for, and/or reward partners, and so intraguild interactions have the potential to influence population dynamics and patterns of selection in species on both sides of the mutualistic interaction. To illustrate some of these potential complexities for population dynamics, I use simple path analytic models to show that positive pairwise interactions between mutualists do not necessarily translate into positive net interactions within a mutualism involving more than two species. For example, when there is intraguild competition for partners, or even for resources external to the mutualism, the presence of a lower-quality mutualist can negatively affect the partner population by reducing associations it can form with better mutualists. Variation in quality among potential partners is likely to place a premium on traits or behaviors that enhance association with better mutualists. More investigations are needed to determine how variation among interacting mutualists, with respect to characteristics such as longevity, dispersal capability, and competitive ability, influence population dynamics and selection in multispecies mutualisms.
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PLoS One
January 2025
Institute for Health Systems Science, Faculty of Technology, Policy and Management, Delft University of Technology, Delft, The Netherlands.
Mathematical modeling plays an important role in our understanding and targeting therapy resistance mechanisms in cancer. The polymorphic Gompertzian model, analyzed theoretically and numerically by Viossat and Noble to demonstrate the benefits of adaptive therapy in metastatic cancer, describes a heterogeneous cancer population consisting of therapy-sensitive and therapy-resistant cells. In this study, we demonstrate that the polymorphic Gompertzian model successfully captures trends in both in vitro and in vivo data on non-small cell lung cancer (NSCLC) dynamics under treatment.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
International Lymphoedema Framework, London, United Kingdom.
Background: The World Health Organization launched the Global Programme to Eliminate Lymphatic Filariasis in 2000, which aimed at eradicating the disease by 2030. This goal depends on community mass drug administration and essential care. Despite these efforts, many rural communities still face untreated lymphatic filariasis and lack access to treatment and self-management.
View Article and Find Full Text PDFAstrobiology
December 2024
Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Bari, Italy.
Agent-based simulations are set to describe the early biotic selection of oligomers made of monomers of different chirality. The simulations consider the spatial distribution of agents and resources, the balance of biomass of different chirality, and the balance of chemical energy. Following the well-known Wald's hypothesis, a disadvantage is attributed to the change in chirality along the biochemical sequence.
View Article and Find Full Text PDFGeroscience
January 2025
Center for Aging and Population Health, School of Public Health, University of Pittsburgh, 310 BelPB, 130 N. Bellefield Avenue, Pittsburgh, PA, 15213, USA.
Unintentional weight loss in older populations is linked to greater mortality and morbidity risks. This study aims to understand the metabolic mechanisms of unintentional weight loss and their relationship with body composition changes in older adults. We investigated plasma metabolite associations with weight and body composition changes over 5 years in 1335 participants (mean age 73.
View Article and Find Full Text PDFElife
January 2025
Department of Neurosurgery, Washington University School of Medicine, Springfield, United States.
Background: Subarachnoid hemorrhage (SAH) is characterized by intense central inflammation, leading to substantial post-hemorrhagic complications such as vasospasm and delayed cerebral ischemia. Given the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation (taVNS) and its ability to promote brain plasticity, taVNS has emerged as a promising therapeutic option for SAH patients. However, the effects of taVNS on cardiovascular dynamics in critically ill patients, like those with SAH, have not yet been investigated.
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