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Erythroid Krüppel-Like Factor (KLF1): A Surprisingly Versatile Regulator of Erythroid Differentiation.
Adv Exp Med Biol
July 2024
Department of Cell Biology, Erasmus MC, Rotterdam, The Netherlands.
Erythroid Krüppel-like factor (KLF1), first discovered in 1992, is an erythroid-restricted transcription factor (TF) that is essential for terminal differentiation of erythroid progenitors. At face value, KLF1 is a rather inconspicuous member of the 26-strong SP/KLF TF family. However, 30 years of research have revealed that KLF1 is a jack of all trades in the molecular control of erythropoiesis.
View Article and Find Full Text PDFGRAVEN: a database of teaching method that applies gestures to represent the neurosurgical approach's blood vessels and nerves.
BMC Med Educ
May 2024
Department of Modern Education Technology Center, Harbin Medical University, Harbin, 150086, China.
Background: In this era of rapid technological development, medical schools have had to use modern technology to enhance traditional teaching. Online teaching was preferred by many medical schools. However due to the complexity of intracranial anatomy, it was challenging for the students to study this part online, and the students were likely to be tired of neurosurgery, which is disadvantageous to the development of neurosurgery.
View Article and Find Full Text PDFBlinding and blurring the multi-object tracker with adversarial perturbations.
Neural Netw
August 2024
Waseda University, Tokorozawa, 359-1192, Japan. Electronic address:
Adversarial attack reveals a potential imperfection in deep models that they are susceptible to being tricked by imperceptible perturbations added to images. Recent deep multi-object trackers combine the functionalities of detection and association, rendering attacks on either the detector or the association component an effective means of deception. Existing attacks focus on increasing the frequency of ID switching, which greatly damages tracking stability, but is not enough to make the tracker completely ineffective.
View Article and Find Full Text PDFPain after amputation is often managed by target muscle reinnervation (TMR) with the added benefit that TMR also provides improved myoelectric terminal device control. However, as TMR takes several months for the recipient muscles to reliably reinnervate, this technique does not address pain within the subacute postoperative period during which pain chronification, sensitization, and opioid dependence and misuse may occur. Cryoneurolysis, described herein, uses focused, extreme temperatures to essentially "freeze" the nerve, blocking nociception, and improving pain in treated nerves potentially reducing the chances of pain chronification, sensitization, and substance dependence or abuse.
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