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Advances in Migraine Treatment: A Comprehensive Clinical Review.
Curr Protein Pept Sci
January 2025
Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur- 603203, Chengalpattu, Tamil Nadu, India.
Migraine is a neurological disease that, while not inherently causing "chronic headaches," can evolve into a chronic condition over time including major symptoms such as nausea, and light, sound, and allodynia, particularly in cases of frequent episodic migraine or due to factors such as medication overuse or inadequate management. This condition's complex pathophysiology makes treatment difficult. Genetics, trigeminovascular system activation, and cortical spreading depression are involved.
View Article and Find Full Text PDFNon-carbapenem-producing carbapenem-resistant Pseudomonas aeruginosa in children: Risk factors, molecular epidemiology, and resistance mechanism.
J Infect Public Health
December 2024
Department of Nosocomial Infection Control, The Clinical Laboratory, Clinical Microbiology Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. Electronic address:
Background: The investigation into risk factors, molecular epidemiology, and resistance mechanisms of carbapenem-resistant Pseudomonas aeruginosa (CRPA) in pediatric populations in China is currently inadequate.
Methods: To assess epidemiology, molecular characteristics, and resistance mechanisms, virulence-associated genes were analyzed, alongside multi locus sequence typing (MLST), PCR, and qRT-PCR.
Finding: Multivariate analysis identified prolonged hospitalization (OR: 1.
Buoyancy-driven flow for surface reaction on vertical walls in multilayered open cavities.
Heliyon
January 2025
Department of Mathematics, University of Dhaka, Dhaka 1000, Bangladesh.
This study analyzes the influences of surface reactions on the natural convective flow, temperature, and oxygen concentration distributions in vertically placed multilayered cavities. A mathematical model for this problem is formulated with proper boundary conditions. At first, the governing equations are made dimensionless using the variable transformations.
View Article and Find Full Text PDFExtended spectrum betalactamase and Carbapenemase producing gram negative bacteria from healthcare workers gowns at Debre Berhan Comprehensive Specialized Hospital, Ethiopia.
Sci Rep
January 2025
Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Extended-spectrum beta-lactamase (ESBL) and carbapenemase-producing (CP) gram-negative bacteria are the major public health concerns. Gowns used by healthcare workers (HCWs) in daily practice are a source of hospital-acquired infections in hospital settings. The study aimed to determine the prevalence of extended-spectrum beta-lactamase and carbapenemase-producing gram-negative bacteria from gowns of healthcare workers at Debre Berhan Comprehensive Specialized Hospital, Amhara Regional State, Ethiopia.
View Article and Find Full Text PDFInfluenza A virus in dairy cattle: infection biology and potential mammary gland-targeted vaccines.
NPJ Vaccines
January 2025
ISP, INRAE, Université de Tours, Nouzilly, France.
Influenza, a major "One Health" threat, has gained heightened attention following recent reports of highly pathogenic avian influenza in dairy cattle and cow-to-human transmission in the USA. This review explores general aspects of influenza A virus (IAV) biology, its interactions with mammalian hosts, and discusses the key considerations for developing vaccines to prevent or curtail IAV infection in the bovine mammary gland and its spread through milk.
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