AI Article Synopsis
- The case study discusses an adult with minimal change nephrotic syndrome (MCNS) resistant to initial steroid and cyclophosphamide treatments.
- Cyclosporin therapy led to severe flushing attacks as a side effect, complicating treatment.
- Switching to tacrolimus effectively improved both the nephrotic syndrome and the skin reactions, highlighting its potential for treating refractory MCNS and other kidney diseases.
Article Abstract
The authors report a case of adult-onset minimal change nephrotic syndrome (MCNS) that was resistant to steroid and cyclophosphamide therapy. Introduction of cyclosporin induced an usual cutaneous reaction of severe flushing attacks. Tacrolimus successfully alleviated both the nephrotic syndrome and the cutaneous side effect associated with cyclosporin use. The antiproteinuric mechanisms of tacrolimus and its potential in treating refractory MCNS and other forms of primary glomerulonephritides are discussed.
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| http://dx.doi.org/10.1016/j.ajkd.2003.07.011 | DOI Listing |
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