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Comparison of pregnancy outcomes in amniocentesis recipients with normal and abnormal maternal serum analytes.
Cell Mol Biol (Noisy-le-grand)
November 2024
Reproductive Health Research Center, Department of Midwifery and Reproductive Health, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Considering the relatively high frequency of genetic disorders associated with negative pregnancy outcomes, in this research, adverse pregnancy outcomes in amniocentesis patients were compared between two groups with normal and abnormal maternal serum analytes. This retrospective cohort study was conducted on singleton pregnant women who underwent amniocentesis and had fetuses with normal chromosomes at the perinatology clinic in Rasht. Eligible patients were divided into two groups of 307 people with normal and abnormal maternal serum analytes based on laboratory screening results.
View Article and Find Full Text PDFCurrent and Evolving Biomarkers in the Diagnosis and Management of Testicular Germ Cell Tumors.
J Clin Med
December 2024
Division of Urology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Article Synopsis
- Testicular cancer is the most common cancer in young adult men, with high survival rates of around 99% for early-stage and over 80% for advanced-stage cases.
- Traditional tumor markers like AFP, β-hCG, and LDH have limited sensitivity and can give false positives, leading to a need for new biomarkers.
- MicroRNA-371a-3p shows promising results in diagnosing germ cell tumors with around 90% sensitivity and may help in treatment decisions, while ongoing clinical trials are validating its effectiveness and exploring other biomarkers like ctDNA and CTCs.
Acute Epiploic Appendagitis Mimicking Ovarian Torsion: A Case Report Highlighting Diagnostic Challenges.
Am J Case Rep
December 2024
Department of Obstetrics and Gynaecology, Raigmore Hospital, NHS Highland, Inverness, United Kingdom.
BACKGROUND Acute epiploic appendagitis is an uncommon cause of acute abdominal pain characterized by pain in the left or right lower quadrants of the abdomen. It is caused by torsion or spontaneous venous thrombosis of one of the epiploic appendages, which are found along the colon, most commonly in the sigmoid colon. The literature consistently compares the presenting symptoms and clinical picture of acute epiploic appendagitis to acute diverticulitis and acute appendicitis.
View Article and Find Full Text PDFSerum β‑hCG as a prognostic marker for colorectal adenocarcinoma in women of reproductive age: A case report and literature review.
Med Int (Lond)
November 2024
Division of Gastroenterology, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Serological and histological examinations have unveiled the presence of free β subunit of human chorionic gonadotropin (β-hCG) in some cases of colorectal adenocarcinoma. The present study describes an unusual case of a young female patient afflicted with rapidly advancing adenocarcinoma of the sigmoid colon. Despite the absence of pregnancy indications on an ultrasound and curettage, a notable elevation of β-hCG was detected in the serum, alongside positive staining in the tumor tissue.
View Article and Find Full Text PDFCorrelation between Human Embryo Morphokinetics Observed through Time-Lapse Incubator and Life Birth Rate.
J Pers Med
October 2024
Department of Medical Disciplines, Faculty of Dentistry, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
(1) Background: Does the variation in sequential development times of embryos, observed through time-lapse monitoring, between the two study groups play a role in predicting pregnancy success? (2) Methods: The prospective double-arm study was to identify the morphokinetic parameters specific to embryos that were capable of implanting and were conducted on 89 embryos cultured in the Esco Miri time-lapse incubator, divided into two groups: Lot A, consisting of 57 embryos that successfully implanted and resulted in life birth rate (LBR), and Lot B (NLB), comprising 32 embryos that did not implant, leading to a negative beta-hCG outcome. (3) Results: Baseline characteristics, including female age, were not found to be statistically significant ( > 0.01).
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