The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the matrix domain protein of the porcine endogenous retrovirus Gag polyprotein, blocks retrovirus production, providing the possibility of eliminating the risk of infection in xenotransplantation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC254262 | PMC |
| http://dx.doi.org/10.1128/jvi.77.22.12132-12139.2003 | DOI Listing |
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