The silica nanoparticles are modified by sodium iodine or sodium chloride with different concentration. Their ability to bind and protect plasmid DNA was demonstrated by agarose gel electrophoresis. The EGFP-N1 plasmid was transfected into HT1080 by combing silica nanoparticle. Eletromicroscope examine revealed that nanoparticle-DNA could enter into cells, these silica nanoparticles protect DNA against nuclease digestion and the GFP has an effective expression. In conclusion, these nanoparticles might be used as DNA carriers for gene transfection.
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