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Computational Methods for Predicting Chemical Reactivity of Covalent Compounds.
J Chem Inf Model
January 2025
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, People's Republic of China.
In recent decades, covalent inhibitors have emerged as a promising strategy for therapeutic development, leveraging their unique mechanism of forming covalent bonds with target proteins. This approach offers advantages such as prolonged drug efficacy, precise targeting, and the potential to overcome resistance. However, the inherent reactivity of covalent compounds presents significant challenges, leading to off-target effects and toxicities.
View Article and Find Full Text PDFRoving pen: minimally invasive mitral surgery.
Indian J Thorac Cardiovasc Surg
February 2025
Government Medical College, Omandurar Government Estate, Chennai 02, Tamilnadu India.
Minimally invasive mitral valve surgery (MIMVS) is revolutionizing the field of cardiothoracic surgery by offering patients less invasive alternatives to conventional sternotomy. This article reviews recent research and studies on the outcomes, challenges, and considerations surrounding MIMVS. Comparative studies reveal that while MIMVS offers advantages such as shorter hospital stays and reduced recovery times, it shows no significant differences in mortality or long-term quality-of-life outcomes compared to traditional methods.
View Article and Find Full Text PDFGravity-Driven Ultrahigh-Speed Electrospinning for the Production of Ethyl Cellulose Fibers with Tunable Porosity for Oil Absorption.
ACS Sustain Chem Eng
January 2025
Department of Chemistry and Biochemistry, Rowan University, Glassboro, New Jersey 08028, United States.
Ethyl cellulose (EC) is a biocompatible, renewable, and recyclable material with diverse sources, making it an attractive candidate for industrial applications. Electrospinning has gained significant attention for the production of EC fibers. However, conventional electrospinning methods face challenges such as bead formation, low yield, and the absence of porous internal structures, limiting both the functional performance and scalability.
View Article and Find Full Text PDFOptimal doses of intranasal esketamine plus dexmedetomidine for sedating toddlers during transthoracic echocardiography: a prospective, double-blind, randomized trial.
Ann Med
December 2025
Department of Anesthesiology, Hunan Children's Hospital, Changsha, Hunan, China.
Introduction: Esketamine has unique advantages in combination with dexmedetomidine for sedation in young children, owing to its sympathetic activity and mild respiratory depression. However, the optimal dose is yet to be determined. In this study, we compared the different doses of intranasal esketamine combined with dexmedetomidine for sedation during transthoracic echocardiography in toddlers.
View Article and Find Full Text PDFApplication of Chinese Medicine in Treatment of Ulcerative Colitis and Elucidation of Relevant Mechanisms.
Chin J Integr Med
January 2025
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, 830017, China.
Ulcerative colitis (UC) is a chronic, non-specific intestinal disease of unknown etiology, with high incidence rates worldwide. At present, Western medicine treatments have been associated with more adverse effects and poor efficacy. Chinese medicine (CM) is commonly used as an adjuvant treatment for the unique advantages in regulating immune function, repairing intestinal mucosa, and alleviating intestinal inflammation.
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