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Natural Products From Plants Targeting Leptin Resistance for the Future Development of Anti-Obesity Agents.
Phytother Res
January 2025
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Obesity is a serious health threat, which has affected 16% of adults globally in 2022 and shows a trend toward youthfulness. Leptin, as a regulator of body weight, can suppress appetite and promote energy expenditure, making it potential in obesity treatment. Nevertheless, with the progress of relevant research, it is worth noting that monotherapy with leptin is not an effective strategy since most obese individuals are hyperleptinemic and resistant to leptin, where high levels of leptin fail to exert its weight-loss effects.
View Article and Find Full Text PDFA Wonderful Journey: The Diverse Roles of Adenosine Deaminase Action on RNA 1 (ADAR1) in Central Nervous System Diseases.
CNS Neurosci Ther
January 2025
Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China.
Background: Adenosine deaminase action on RNA 1 (ADAR1) can convert the adenosine in double-stranded RNA (dsRNA) molecules into inosine in a process known as A-to-I RNA editing. ADAR1 regulates gene expression output by interacting with RNA and other proteins; plays important roles in development, including growth; and is linked to innate immunity, tumors, and central nervous system (CNS) diseases.
Results: In recent years, the role of ADAR1 in tumors has been widely discussed, but its role in CNS diseases has not been reviewed.
Providing medically tailored groceries and food resource coaching through the charitable food system to patients of a safety-net clinic in Dallas, Texas: a randomised controlled trial protocol.
BMJ Open
January 2025
O'Donnell School of Public Health, UT Southwestern Medical Center, Dallas, Texas, USA
Introduction: Linking patients living with chronic, diet-related diseases and food insecurity to charitable food assistance, medically tailored groceries (MTGs) and food resource coaching may empower patients to better manage their health in a way that is economically sustainable. This protocol paper describes the implementation of a study evaluating MTGs and food resource coaching in a food pantry setting.
Methods And Analysis: A randomised controlled trial whereby patients of a safety-net health centre will be screened for The Emergency Food Assistance Program (TEFAP) and study eligibility.
Clinical Manifestations.
Alzheimers Dement
December 2024
University of North Texas Health Science Center, Fort Worth, TX, USA.
Background: The concept of motoric cognitive risk (MCR) combines subjective cognitive concern (SCC) with slowed gait speed. The concept allows for the incorporation of cognitive and functional slowing into a measure of risk assessment. This study explores differences in cognitive functioning in cognitively unimpaired older adults with MCR and those without subjective cognitive concern and without slow gait speed.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of North Texas Health Science Center, Fort Worth, TX, USA.
Background: Mild cognitive function (MCI) is associated with a declined short-term memory (STM). This study compared STM between adults with MCI and normal cognition assessed by verbal memory vs visuospatial memory.
Methods: Sixteen subjects with MCI and 11 subjects with normal cognition gave their written consent to participate in the study which was approved by the North Texas Regional IRB.
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