Hyperfoliatin, a new polyisoprenylated phloroglucinol derivative was isolated from the aerial parts of Hypericum perfoliatum (Clusiaceae) collected in Algeria. The structure of hyperfoliatin was elucidated on the basis of its spectral data, mainly MS and multiple-pulse NMR.
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Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum.
Fitoterapia
December 2016
Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi 830004, People's Republic of China.
Four new polyisoprenylated benzoylphloroglucinol derivatives, hyperscabrones J-M (1-4), were isolated from the air-dried aerial parts of Hypericum scabrum. Their structures were elucidated by spectroscopic methods and were subsequently confirmed by comparing with data of known compounds. The absolute configuration of the bicyclo[3.
View Article and Find Full Text PDFPolyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii.
J Nat Prod
November 2007
School of Pharmacy, Fudan University, Shanghai 200032, People's Republic of China.
Bioassay-directed fractionation using multidrug-resistant (MDR) Staphylococcus aureus resulted in the isolation of four new polyprenylated benzophloroglucinol derivatives, sampsoniones N-Q (1-4), and four known compounds, 7-epiclusianone (5) and sampsoniones B, L, and R, from the roots of Hypericum sampsonii. The structures of these compounds were established by analysis of spectroscopic data, and the structures of 4 and 5 were determined by single-crystal X-ray diffraction crystallography. In the bioassay, 7-epiclusianone (5) showed promising activity with a minimum inhibitory concentration (MIC) of 7.
View Article and Find Full Text PDFAntidepressant-like effect of hyperfoliatin, a polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae) is associated with an inhibition of neuronal monoamines uptake.
Eur J Pharmacol
August 2007
CNRS FRE 2735, Laboratory of Experimental Neuropsychopharmacology, European Institute for Peptide Research (IFRMP 23), Faculty of Medicine and Pharmacy, Institute of Biomedical Research, University of Rouen, France.
This study investigated, in mice, the antidepressant like effect of hyperfoliatin, a prenylated phloroglucinol derivative isolated from the aerial parts of Hypericum perfoliatum, as well as its action on monoaminergic systems. In the forced-swimming test, hyperfoliatin dose-dependently reduced immobility time. Immobility was interpreted as an expression of "behavioural despair", which could be a component of depression syndrome.
View Article and Find Full Text PDFA new polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae).
Z Naturforsch C J Biosci
January 2004
Département de Chimie, Faculté des Sciences, Université Colonel El-Hadj Lakhdar, 05000 Batna, Algeria.
Hyperfoliatin, a new polyisoprenylated phloroglucinol derivative was isolated from the aerial parts of Hypericum perfoliatum (Clusiaceae) collected in Algeria. The structure of hyperfoliatin was elucidated on the basis of its spectral data, mainly MS and multiple-pulse NMR.
View Article and Find Full Text PDFLaxifloranone, a new phloroglucinol derivative from Marila laxiflora.
J Nat Prod
August 1999
Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.
A new polyisoprenylated phloroglucinol derivative has been isolated from the twigs of Marila laxiflora and characterized on the basis of 1D and 2D NMR spectra. Laxifloranone (1) shows moderate inhibition of the cytopathic effects of in vitro HIV infection.
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