Background: 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") can mediate acute toxic effects such as muscle rigidity, metabolic acidosis, and hyperthermia. Because of close clinical similarities, an association between MDMA intoxication and malignant hyperthermia (MH) was suggested. The aim of this study was to investigate whether MDMA is a trigger of MH in susceptible swine.
Methods: MH-nontriggering general anesthesia was performed in six MH-susceptible (MHS) and six MH-normal swine. The animals were exposed to MDMA in cumulative doses of 0.5, 1, 2, 4, 8, and 12 mg/kg. The clinical occurrence of MH was defined by achievement of two of three conditions: central venous Pco2 >/=75 mmHg, central venous pH /= 2.0 degrees C. Once MH occurred, a standardized therapy with dantrolene, sodium bicarbonate, and hyperventilation with 100% oxygen was initialized.
Results: Administration of 8 mg/kg MDMA triggered MH in all MHS swine. The MH-normal swine also developed clinical signs of hypermetabolism, but even after administration of 12 mg/kg MDMA, changes were moderate compared with the MHS swine. Dantrolene therapy of MDMA-induced MH crisis in the MHS swine partially counteracted the clinical signs of MH immediately.
Conclusions: MDMA induces MH in genetically susceptible swine in relevant doses. Therefore, MHS patients should avoid use of MDMA or related drugs. Patients with a personal or family history of MDMA-induced hyperthermia should be tested for a diagnosis of MH susceptibility. Dantrolene is effective in therapy of MDMA-induced porcine MH.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00000542-200311000-00020 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dynamics of antibody response and bacterial shedding of Mycoplasma hyorhinis and M. hyosynoviae in oral fluids from experimentally inoculated pigs.
Vet Microbiol
March 2024
Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA, USA. Electronic address:
Mycoplasma hyorhinis (Mhr) and M. hyosynoviae (Mhs) are commensal organisms of the upper respiratory tract and tonsils but may also cause arthritis in pigs. In this study, 8-week-old cesarean-derived colostrum-deprived (CDCD) pigs (n = 30; 3 groups, 10 pigs per group, 2 pigs per pen) were inoculated with Mhr, Mhs, or mock-inoculated with culture medium and then pen-based oral fluids were collected at different time points over the 56 days of the experimental study.
View Article and Find Full Text PDFEx vivo and in vivo evaluation of transsphenoidal Liqoseal application to prevent cerebrospinal fluid leakage.
Acta Neurochir (Wien)
June 2023
Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Background: Despite improvements in closure techniques by using a vital nasoseptal flap, the use of sealing materials, and improved neurosurgical techniques, cerebrospinal fluid (CSF) leak after transsphenoidal surgery still is a clinically relevant problem. Liqoseal® (Polyganics bv, Groningen, The Netherlands) is a CE-approved bioresorbable sealant patch for use as an adjunct to standard methods of cranial dural closure to prevent CSF leakage. This study aims to evaluate the application of Liqoseal in transsphenoidal surgery ex vivo and in vivo.
View Article and Find Full Text PDFComparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use?
Stroke
April 2022
Division of Experimental Cardiology, Department of Cardiology (A.T., J.B., D.J.D., H.M.M.v.B.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Article Synopsis
- Translation of acute ischemic stroke research to clinical practice has been slow, with only one drug approved, highlighting the need for better experimental treatment selection before clinical testing.
- Large gyrencephalic animal models such as dogs, swine, sheep, and nonhuman primates are recommended for research because they closely mimic human brain conditions during ischemia and reperfusion.
- The article reviews key factors in choosing the right large animal models for acute ischemic stroke research, focusing on cerebral anatomy, ischemic modeling techniques, and practical aspects like ethics and costs.
Establishment of a Modular Hemodynamic Simulator for Accurate In Vitro Simulation of Physiological and Pathological Pressure Waveforms in Native and Bioartificial Blood Vessels.
Cardiovasc Eng Technol
April 2022
Hannover Medical School, Lower Saxony Centre for Biomedical Engineering, Implant Research and Development (NIFE), Stadtfelddamm 34, 30625, Hannover, Germany.
Purpose: In vitro stimulation of native and bioartificial vessels in perfusable systems simulating natural mechanical environments of the human vasculature represents an emerging approach in cardiovascular research. Promising results have been achieved for applications in both regenerative medicine and etiopathogenetic investigations. However, accurate and reliable simulation of the wide variety of physiological and pathological pressure environments observed in different vessels still remains an unmet challenge.
View Article and Find Full Text PDFCorrelations between cardiovascular parameters and image parameters on dynamic chest radiographs in a porcine model under fluid loading.
Radiol Phys Technol
September 2021
Clinical Engineering, Komatsu University, 10-10 Doihara-cho, Komatsu, Ishikawa, 923-0921, Japan.
Latest digital radiographic technology permits dynamic chest radiography during the cardiac beating and/or respiration, which allows for real-time observation of the lungs. This study aimed to assess the capacity of dynamic flat-panel detector (FPD) imaging without the use of contrast media to estimate cardiovascular parameters based on image parameters of a porcine model under fluid loading. Three domestic pigs were intubated, and mechanical ventilation was provided using a ventilator under anesthesia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!