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G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate. | LitMetric
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G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate.

Laura Rodero Emilia Mellado A Carolina Rodriguez Angela Salve Liliana Guelfand Pedro Cahn Manuel Cuenca-Estrella Graciela Davel Juan L Rodriguez-Tudela

Antimicrob Agents Chemother

Departamento Micología, Instituto Nacional de Enfermedades Infecciosas, ANLIS Dr. Carlos G. Malbrán, Hospital J. A. Fernandez, Buenos Aires, Argentina.

Published: November 2003

Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC253790PMC
http://dx.doi.org/10.1128/AAC.47.11.3653-3656.2003DOI Listing

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