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The Transformative Power of Embodied Behaviour: Influencing Tourists' Experience in the Guangzhou Marathon as a Mass Participant Sports Event.
Behav Sci (Basel)
January 2025
Department of Tourism Management, South China University of Technology, Guangzhou 510006, China.
Mass-participation sports events (MPSEs) are of significant value to the fields of sports, culture, and tourism. MPSEs have witnessed a remarkable surge in popularity, which has led to a complex interplay of factors influencing participants' overall experience, making it crucial to understand the role of embodied behaviour. However, the existing literature is deficient in terms of providing substantial evidence, particularly with regard to the growing significance of experience planning as a core aspect of event design.
View Article and Find Full Text PDF[Local injections of glucocorticoids at different regions in the treatment of sudden sensorineural hearing loss: a Meta-analysis].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2025
Department of Pathology and Pathophysiology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing210023, China.
To compare the efficacy and safety of postauricular injection (PI) and intratympanic injection (II) of glucocorticoids (GC) in the initial treatment of sudden sensorineural hearing loss (SHL). Electronic databases retrieval (PubMed, Web of Science, CNKI, VIP, WANFANG) was performed to identify all randomized controlled trials about PI and II of GC in the initial treatment of SHL between 2015 and 2024. Meta-analysis was performed on the studies met the inclusion criteria by RevMan5.
View Article and Find Full Text PDFDesign, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases.
Eur J Med Chem
January 2025
Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:
Cholestatic liver disease (CLD) represents a significant and growing public health concern, and there is a lack of effective therapeutic drug in clinical practice. Peroxisome proliferator-activator receptors α/δ (PPARα/δ) are regarded as potential therapeutic targets for CLD. In this study, a series of novel imidazolidinone PPARα/δ agonists were developed, and the preferred compound 8 displayed potent and well-balanced agonistic activity.
View Article and Find Full Text PDFElectrospinning based biomaterials for biomimetic fabrication, bioactive protein delivery and wound regenerative repair.
Regen Biomater
December 2024
Department of Trauma Surgery, Orthopaedic Surgery and Plastic Surgery, University Medical Center Göttingen, University of Göttingen, Göttingen 37075, Germany.
Electrospinning is a remarkably straightforward and adaptable technique that can be employed to process an array of synthetic and natural materials, resulting in the production of nanoscale fibers. It has emerged as a novel technique for biomedical applications and has gained increasing popularity in the research community in recent times. In the context of tissue repair and tissue engineering, there is a growing tendency toward the integration of biomimetic scaffolds and bioactive macromolecules, particularly proteins and growth factors.
View Article and Find Full Text PDFHyaluronic acid/silk fibroin nanoparticles loaded with methotrexate for topical treatment of psoriasis.
Int J Pharm X
June 2025
State Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Yibin Academy, Southwest University, Chongqing 400715, China.
Systemic administration of methotrexate (MTX), widely regarded as one of the most effective treatments for psoriasis, poses significant challenges due to its high toxicity, limited solubility, and potential for adverse effects. Consequently, developing a topical form of MTX may offer a safer and more effective strategy for psoriasis management. Silk fibroin (SF), a protein-based biomacromolecule, has shown considerable promise as a nanocarrier for sustained and targeted drug delivery, owing to its exceptional physicochemical and biological properties.
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