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[DiGeorge syndrome with 22q11.2 deletion in a patient of Rarámuri ethnicity].
Rev Alerg Mex
December 2024
Departamento de Inmunología, Hospital Infantil de Especialidades de Chihuahua; Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua.
Background: 22q11 deletion syndrome consists of a variable grouping of phenotypic features and immunological defects secondary to the loss of genetic material located in the 22q11.2 band. The 22q11 deletion spectrum encompasses different syndromes related to the same etiology and with overlapping anomalies, including DiGeorge syndrome, velocardiofacial syndrome, among others.
View Article and Find Full Text PDFCollaborative machine learning-guided overall survival prediction of oral squamous cell carcinoma.
Acta Otolaryngol
December 2024
Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Article Synopsis
- The study addresses the need for better survival predictions for patients with Oral Squamous Cell Carcinoma (OSCC) by utilizing collaborative machine learning (cML) methods.
- Five machine learning models were tested on a dataset of 9,439 OSCC patients, showing varying accuracy levels, with the voting ensemble model being the most accurate at 70.2%.
- Key prognostic factors impacting overall survival included age, tumor stage, surgery, and treatment modalities, suggesting that cML could improve personalized treatment strategies for OSCC patients.
Anatomical variations in pneumatization types and volume of sphenoid sinus in a subset of Pakistani people.
J Pak Med Assoc
December 2024
Department of Anatomy, Dow University of health Sciences, Karachi, Pakistan.
Objective: To evaluate the relationship between volume and pneumatization pattern of sphenoid sinus using computed tomography images.
Methods: The prospective, cross-sectional study was conducted at the Radiology Department of Dow University of Health Sciences, Karachi, from October 2020 to February 2021, and comprised patients of either gender aged 20-70 years who were subjected to computed tomography of paranasal sinuses. The scans were analysed for sphenoid volume and four pneumatization types of sphenoid sinus, including Type-I conchal, Type-II presellar, Type-III sellar and Type-IV postsellar.
A Study of the Acoustic Voice Parameters Among Older Thai People in Chiang Mai.
J Voice
December 2024
Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Unlabelled: This cross-sectional study aimed to examine acoustic voice parameters among older Thai individuals in Chiang Mai-a northern Thai province with the third-largest elderly population and significant PM exposure-and to compare these measures between normal and abnormal voice groups within this population.
Method: The study involved 125 Thai elderly with normal voices, who were selected through a multi-stage sampling process and assessed by using the GRBASI scale (Grade, Roughness, Breathiness, Asthenia, Strain, Instability), and 45 elderly Thai individuals with abnormal voices, selected through purposive sampling and diagnosed by an Ear, Nose, and Throat (ENT) doctor or assessed by using the GRBASI scale. Additionally, participants with normal voices underwent a speech discrimination test before voice recording.
Defining within-host SARS-CoV-2 RNA viral load kinetics during acute COVID-19 infection within different respiratory compartments and their respective associations with host infectiousness: a protocol for a systematic review and meta-analysis.
BMJ Open
December 2024
Development Centre for Population Health, University of Leicester, Leicester, UK
Introduction: Understanding how RNA viral load changes (viral load kinetics) during acute infection in SARS-CoV-2 can help to identify when and which patients are most infectious. We seek to summarise existing data on the longitudinal RNA viral load kinetics of SARS-CoV-2 sampled from different parts of the respiratory tract (nose, nasopharynx, oropharynx, saliva and exhaled breath) and how this may vary with age, sex, ethnicity, immune status, disease severity, vaccination, treatment and virus variant.
Methods And Analysis: We will conduct a systematic review and meta-analysis, using studies identified through MEDLINE and EMBASE (via Ovid).
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