Introduction: An intraspinal teratoma that is located entirely extradurally is unusual both in children and in adults.
Case History: The authors present a case of an 8-month-old male infant with an extradurally arising intraspinal mature teratoma located from T-2 to T-4, who had suffered from progressive paraparesis (grade 1). The patient did not have any stigmata or anomalies suggesting spinal dysraphism. Spinal MRI showed a cystic extradural mass markedly compressing the dural sac. On operation, the only way of getting sufficient space for exposure of the whole tumor was to perform hemilaminectomies with preservation of facetal areas to prevent postoperative instability. The tumor was well encapsulated and located entirely extradurally, and the cystic portion was occupied with yellowish fluid. The site of tumor occurrence was the spinal root sheath, mimicking a neural sheath tumor. Paraparesis had improved markedly to grade 4 by the time of the neurological examination 3 months after operation.
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http://dx.doi.org/10.1007/s00381-003-0821-2 | DOI Listing |
Neural Regen Res
January 2025
School of Medicine, Keele University, Newcastle-under-Lyme, UK.
Functional recovery in penetrating neurological injury is hampered by a lack of clinical regenerative therapies. Biomaterial therapies show promise as medical materials for neural repair through immunomodulation, structural support, and delivery of therapeutic biomolecules. However, a lack of facile and pathology-mimetic models for therapeutic testing is a bottleneck in neural tissue engineering research.
View Article and Find Full Text PDFElife
January 2025
Center for Medical Genetics Ghent, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Heritable fragile bone disorders (FBDs), ranging from multifactorial to rare monogenic conditions, are characterized by an elevated fracture risk. Validating causative genes and understanding their mechanisms remain challenging. We assessed a semi-high throughput zebrafish screening platform for rapid in vivo functional testing of candidate FBD genes.
View Article and Find Full Text PDFJ Mater Chem B
January 2025
Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.
Single-atom nanozymes (SAzymes) with excellent biological catalytic activity have emerged as promising candidates for advancing biomedical applications. Herein, we synthesized a RuN-SAzyme by thermal decomposition. In experiments, the RuN-SAzyme demonstrated exceptional catalytic efficiency in mimicking the activity of peroxidase, with a Michaelis-Menten constant () for 3,3',5,5'-tetramethylbenzidine reaching 0.
View Article and Find Full Text PDFJ Peripher Nerv Syst
March 2025
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Background And Aims: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is difficult to distinguish from mimicking disorders, with misdiagnosis resulting in IVIG overutilization. We evaluate a clinical-electrophysiological model to facilitate CIDP versus mimic neuropathy prediction.
Methods: Using the European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) 2021 CIDP guidelines we derived 26 clinical and 144 nerve conduction variables.
Molecules
December 2024
Chair for Integrated Systems and Photonics, Department of Electrical and Information Engineering, Faculty of Engineering, Kiel University, Kaiserstr. 2, 24143 Kiel, Germany.
Biological neural circuits are based on the interplay of excitatory and inhibitory events to achieve functionality. Axons form long-range information highways in neural circuits. Axon pruning, i.
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