AI Article Synopsis
- Unilateral intracarotid injection of contrast agents can significantly disrupt the blood-brain barrier in rats, resulting in vasogenic edema on the same side (ipsilateral hemisphere).
- Administering ultrasound contrast agents after mild traumatic brain injury greatly increases mortality and leakage of fluids.
- This method of direct contrast agent administration highlights edema-related issues and can worsen outcomes in studies involving neurotrauma.
Article Abstract
Unilateral intracarotid injection of contrast agents may considerably destabilize the blood-brain barrier in rats. This leads to vasogenic edema in the ipsilateral hemisphere. Mortality and extravasation increased significantly when administration of these ultrasound contrast agents was followed by mild traumatic brain injury. Direct administration to the cerebral circulation is, therefore, indicative for edema-related pathology and may amplify the consequences of experimental neurotrauma.
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| http://dx.doi.org/10.1046/j.1440-1789.2003.00505.x | DOI Listing |
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