We intended to study the effect of swimming exercise on the brain, liver and heart malondialdehyde (MDA) levels which are the last product of oxidation, and to compare them with the brain, liver and heart MDA levels of controls. The experiments were carried out on 20 Wistar rats which were fed with a standard laboratory chow diet ad libitum. Rats were distributed in two groups, control group (n = 10) and exercise group (n = 10). The exercise group rats were exposed to swimming exercise for 30 minutes. After this animals in each group were sacrificed by decapitation, their brain, liver and heart tissues were quickly removed. MDA levels of the brain, liver and heart were determined according to the method in which MDA reacts with thiobarbituric acid. Results were evaluated by the Mann-Whitney U test. The liver and heart MDA levels in the exercise group were (29.59+/-6.73 and 10.49+/-1.90 nmol/g tissue, respectively) significantly higher than in the control group (21.78+/-3.46 and 8.86+/-1.25 nmol/g tissue, p<0.01 and p<0.05, respectively). However, the brain MDA levels were similar in both groups (exercise group 19.37+/-5.50 nmol/g tissue and control group 16.58+/-2.44 nmol/g tissue; p=0.325). It is concluded that swimming exercise might cause oxidative stress.
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Clin Nucl Med
January 2025
From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
Purpose: This study aimed to assess the biodistribution and radiation dosimetry of 68Ga-DATA5m LM4 in patients with gastroenteropancreatic neuroendocrine tumors.
Patients And Methods: Eight patients (5 females and 3 males) with various gastroenteropancreatic neuroendocrine tumors were included in the study. Each patient underwent 3 whole-body PET scans at 10, 60, and 120 minutes after receiving an IV injection of approximately 162.
Front Med (Lausanne)
December 2024
Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan Province, China.
Objective: To explore the relationship between hypertensive disorders of pregnancy (HDP) and adverse pregnancy outcomes and explore the risk factors for HDP.
Methods: Data were obtained from the Maternal Near-Miss Surveillance System in Hunan Province, China, 2012-2022. Chi-square trend tests ( ) were used to determine trends in prevalence by year.
Front Endocrinol (Lausanne)
December 2024
Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Background: The debate persists regarding whether metabolic dysfunction-associated steatotic liver disease (MASLD) actively contributes to coronary heart disease or merely acts as a passive indicator.
Objective: This research aims to clarify the relationship between liver fat accumulation, as quantified by FLI, and the risk of developing coronary heart disease.
Methods: Conducted from April to November 2011, the REACTION project, spearheaded by the Endocrinology Branch of the Chinese Medical Association, focused on Chinese adults aged 40 and above.
Expert Rev Clin Pharmacol
January 2025
Department of Internal Medicine and Cardiology, University Hospital Ostrava, Ostrava, Czech Republic.
Background: The cardioselective β-1 receptor antagonist metoprolol is used to treat heart failure. It is metabolized in the liver, primarily by cytochrome 2D6.
Research Design And Methods: In this study, trough serum concentrations of metoprolol and its metabolite α-hydroxymetoprolol were measured in patients with heart failure with reduced ejection fraction.
J Anim Physiol Anim Nutr (Berl)
January 2025
Department of Animal Nutrition, Lorestan University, Khorramabad, Iran.
This meta-analysis was performed to evaluate the effects of vitamin C (Vit C) supplementation on broiler performance, blood parameters, carcass characteristics and meat quality under heat stress. Based on searches conducted on PubMed, Scopus, Google Scholar and Web of Science, 35 studies published in authoritative journals from 1985 to 2023 were meta-analysed. Heterogeneity was explored by meta-regression analysis.
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