Intussusception, although a common cause of pediatric surgical emergencies, is a rarely fatal condition. A 7-month-old infant who was discovered in her cot was unresponsive and pronounced dead after 2 h of uneventful cardiopulmonary resuscitation in an emergency hospital. Forensic autopsy which was performed in order to clarify the circumstances surrounding the death revealed intussusceptions at two sites of the ileum. Although morbidity and mortality rates from the condition have progressively declined in recent decades but avoidable deaths still occur as was experienced in the present case. The forensic pathology significance in this case was the occurrence of 'painless intussusception' whereby the affected child clinically exhibited no discomfort or characteristic features of acute abdomen until death. In summary, the present case has exhibited an uncommon fatal occurrence and demonstrated the importance of forensic autopsy in such unexpected sudden infant deaths.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/s1344-6223(03)00056-7 | DOI Listing |
Forensic Sci Med Pathol
January 2025
Department of Law, Institute of Legal Medicine, University of Macerata, Macerata, Italy.
Purpose: Hypothermia occurs when core body temperature drops below 35 °C. The purpose of this review was to identify and analyze studies on the topic of hypothermia from an immunohistochemical perspective to determine robust markers of fatal hypothermia.
Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines.
Alzheimers Dement
December 2024
Department of Clinical Sciences Lund, Lund University, Lund, Lund, Sweden.
Background: The amygdala is a hotspot for neuropathologies; however, it is unclear 1) which neuropathologies lead to amygdala neurodegeneration, 2) what specific amygdala subnuclei are affected, and 3) if the neuropathologies related to amygdala volume are local (inside the amygdala), or distal (in other regions). We investigate the relationships between different neuropathologies (tau, amyloid-β [Aβ], α-synuclein [α-syn], and transactive response DNA-binding protein 43 [TDP-43]) and amygdala volumes.
Method: We analyzed postmortem data from 73 individuals with and without neurodegenerative diseases (age: 77±11 [45-101] years; 26 [36%] females; 51 [70%] cognitively impaired).
Alzheimers Dement
December 2024
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.
Background: The unique lesion of chronic traumatic encephalopathy (CTE) is the perivascular deposition of hyperphosphorylated tau at the depth of the cortical sulci. The distribution and molecular composition of p-tau is distinct from Alzheimer's disease (AD), but differential diagnostic challenges remain. Understanding disease differences in regional density of p-tau will inform differential diagnosis and interpretation of in vivo biomarkers.
View Article and Find Full Text PDFBackground: Despite recent advances in biomarkers discovery for neurodegenerative diseases, there are currently no in vivo biomarkers for limbic-predominant age-related TDP-43 encephalopathy (LATE-NC). A few studies have suggested that plasma TDP-43 can be an in vivo marker of frontotemporal dementia due to TDP-43 pathology and amyotrophic lateral sclerosis. In this pilot study, we aimed to assess plasma TDP-43 concentrations as a biomarker in individuals with autopsy confirmed LATE-NC.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
UCSF Alzheimer's Disease Research Center, San Francisco, CA, USA.
Background: Racial differences in dementia prevalence and incidence were found with higher dementia burden in African descendants. Previous neuropathological studies were conducted mostly in white participants in convenience samples. Further studies in diverse populations are important to foster the understanding of race differences in dementia pathology.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!