Modulation of neuronal impulse pattern is examined by means of a simplified Hodgkin-Huxley type computer model which refers to experimental recordings of cold receptor discharges. This model essentially consists of two potentially oscillating subsystems: a spike generator and a subthreshold oscillator. With addition of noise the model successfully mimics the major types of experimentally recorded impulse patterns and thereby elucidate different resonance behaviors. (1) There is a range of rhythmic spiking or bursting where the spike generator is strongly coupled to the subthreshold oscillator. (2) There is a pacemaker activity of more complex interactions where the spike generator has overtaken part of the control. (3) There is a situation where the two subsystems are decoupled and only resonate with the help of noise.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0303-2647(03)00108-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost.
Nat Commun
January 2025
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Neutralizing antibody titer has been a surrogate endpoint for guiding COVID-19 vaccine approval and use, although the pandemic's evolution and the introduction of variant-adapted vaccine boosters raise questions as to this surrogate's contemporary performance. For 985 recipients of an mRNA second bivalent or monovalent booster containing various Spike inserts [Prototype (Ancestral), Beta, Delta, and/or Omicron BA.1 or BA.
View Article and Find Full Text PDFAngular dependence of random laser emission by using ZnO-CuO heterostructure as scatterer and its applications in biocompatible imaging.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Laser Laboratory, Dept. of Physics, The University of Burdwan, Burdwan 713104, India.
The angular dependence of random laser (RL) generation in a commercially available rhodamine 6G (Rh6G) dye has been demonstrated using ZnO-CuO heterostructure as passive scatterers. The grass-like superstructure formed at a 1M:1M molar ratio of ZnO-CuO significantly enhances scattering, resulting in RL spikes with a full width at half maximum (FWHM) of just a few nanometer and a noticeable reduction in the RL threshold. RL emission spectra were collected over an angular spread of 0-180 degrees, revealing a remarkable shift in RL emission from 566 nm to 580 nm.
View Article and Find Full Text PDFMultipronged strategy for protection and motivation of healthcare workers during the COVID-19 pandemic: a real-life study.
Antimicrob Steward Healthc Epidemiol
July 2024
Department of Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Objective: We aimed to assess risk of COVID-19 infection & seroprotection status in healthcare workers (HCWs) in both hospital and community settings following an intensive vaccination drive in India.
Setting: Tertiary Care Hospital.
Methods: We surveyed COVID-19 exposure risk, personal protective equipment (PPE) compliance, vaccination status, mental health & COVID-19 infection rate across different HCW cadres.
Japan's Growing Public Health Crisis: Tackling the Alarming Increase in Streptococcal Toxic Shock Syndrome.
Cureus
December 2024
Gastroenterology, School of Digestive and Liver Diseases, Institute of Postgraduate Medical Education and Research, Kolkata, IND.
Japan is experiencing a dramatic spike in streptococcal toxic shock syndrome (STSS) cases, exceeding the previous year's statistics. This life-threatening illness, caused by , has been connected not only to the relaxation of COVID-19 precautions but also to the prolonged effects of confinement and lack of contact with the surrounding environment/ecology. The condition is characterized by a sudden onset of symptoms, including high fever, rash, and shock, and demands immediate medical intervention.
View Article and Find Full Text PDFDifferentiating the contributions of Na/K pump current and persistent Na current in simulated voltage-clamp experiments.
J Neurophysiol
January 2025
Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
The persistent Na current (I) is thought to play important roles in many brain regions including the generation of inspiration in the ventral respiratory column (VRC) of mammals. The characterization of the slow inactivation of I requires long-lasting voltage steps (>1 s), which will increase intracellular Na and activate the Na/K-ATPase pump current (I). Thus, I may contribute to the previously measured slow inactivation of I and the generation of the inspiratory bursting rhythm.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!