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Explanatory review on DDR inhibitors: their biological activity, synthetic route, and structure-activity relationship.
Mol Divers
January 2025
Integrated Drug Discovery Centre, Department of Pharmaceutical Chemistry, Acharya & BM Reddy College of Pharmacy, Bengaluru, 560107, Karnataka, India.
Discoidin domain receptors (DDR) are categorized under tyrosine kinase receptors (RTKs) and play a crucial role in various etiological conditions such as cancer, fibrosis, atherosclerosis, osteoarthritis, and inflammatory diseases. The structural domain rearrangement of DDR1 and DDR2 involved six domains of interest namely N-terminal DS, DS-like, intracellular juxtamembrane, transmembrane juxtamembrane, extracellular juxtamembrane intracellular kinase domain, and the tail portion contains small C-tail linkage. DDR has not been explored to a wide extent to be declared as a prime target for any particular pathological condition.
View Article and Find Full Text PDFComparative study of Mg/Al-LDH and Mg/Fe-LDH on adsorption and loss control of 2,4-dichlorophenoxyacetic acid.
Adv Biotechnol (Singap)
January 2025
School of Agriculture and Biotechnology, Sun Yat-Sen University, Shenzhen, Guangdong, 518107, People's Republic of China.
Low efficiency and high surface runoff of 2,4-dichlorophenoxyacetic acid (2,4-D) from agricultural field threaten crop yield severely. Layered double hydroxides (LDH) have shown promising adsorption properties for 2,4-D. However, the comparison of two environmentally friendly LDHs (i.
View Article and Find Full Text PDFImpacts of ammoniacal odour removal bioagent on air bacterial community.
Adv Biotechnol (Singap)
February 2024
School of Minerals Processing and Bioengineering, Central South University, Changsha, 410083, China.
While biotechnologies offer eco-friendly solutions for eliminating air contaminants, there is a scarcity of research examining the impacts of microbial purification of air pollutants on the structure and function of air microbial communities. In this study, we explored a Lactobacillus paracasei B1 (LAB) agent for removing ammoniacal odour. The impacts of LAB on air bacterial community were revealed.
View Article and Find Full Text PDFDecoding the genetic blueprint: regulation of key agricultural traits in sorghum.
Adv Biotechnol (Singap)
September 2024
School of Agriculture and Biotechnology, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Sorghum, the fifth most important crop globally, thrives in challenging environments such as arid, saline-alkaline, and infertile regions. This remarkable crop, one of the earliest crops domesticated by humans, offers high biomass and stress-specific properties that render it suitable for a variety of uses including food, feed, bioenergy, and biomaterials. What's truly exciting is the extensive phenotypic variation in sorghum, particularly in traits related to growth, development, and stress resistance.
View Article and Find Full Text PDFWater-saving techniques: physiological responses and regulatory mechanisms of crops.
Adv Biotechnol (Singap)
October 2023
Department of Biology, Hong Kong Baptist University, and State Key Laboratory of Agro-Biotechnology, Chinese University of Hong Kong, Hong Kong, 999077, China.
Water-saving irrigation techniques play a crucial role in addressing water scarcity challenges and promoting sustainable agriculture. However, the selection of appropriate water-saving irrigation methods remains a challenge in agricultural production. Additionally, the molecular regulatory mechanisms of crops under water-saving irrigation are not yet clear.
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