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Mesenchymal stem/stromal cells (MSCs) offer promising therapeutic potential in cell-based therapies for various diseases. However, the safety of genetically modified MSCs remains poorly understood. This study aimed to evaluate the general toxicity and safety of Wharton's Jelly-Derived MSCs (WJ-MSCs) engineered to express the antimicrobial peptide SE-33 in an animal model.
View Article and Find Full Text PDFSegmentation of 3D OCT Images of Human Skin Using Neural Networks with U-Net Architecture.
Sovrem Tekhnologii Med
March 2025
PhD, Senior Researcher; A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, 46 Ulyanov St., Nizhny Novgorod, 603950.
Unlabelled: is a comparative analysis of algorithms for segmentation of three-dimensional OCT images of human skin using neural networks based on U-Net architecture when training the model on two-dimensional and three-dimensional data.
Materials And Methods: Two U-Net-based network architectures for segmentation of 3D OCT skin images are proposed in this work, in which 2D and 3D blocks of 3D images serve as input data. Training was performed on thick skin OCT images acquired from 7 healthy volunteers.
Efficacy Evaluation of "Enhanced" Natural Killers with and Knockouts on Viability and Metabolic Status of 3D Glioblastoma Spheroid Cells in Patients.
Sovrem Tekhnologii Med
March 2025
MD, PhD, Senior Researcher, Laboratory of Cell Technologies; Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russia, 28 Orekhovy Blvd., Moscow, 115682, Russia; Head of the Laboratory of Solid Tumor Immunotherapy; Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russia, 1, Bldg. 10, Ostrovityanova St., Moscow, 117513, Russia; Senior Researcher, Laboratory of Molecular Regeneration Mechanisms; Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow, 119991, Russia.
Unlabelled: One of the alternative approaches to glioblastoma treatment is cellular immunotherapy based on natural killer cells (NK cells). To enhance their cytotoxic effect on tumor cells, new NK cell lines are being created using genetic engineering techniques. was to evaluate the impact efficacy of "enhanced" NK cells on early metabolic rearrangements and the viability of glioblastoma cells in a patient using a tumor spheroid model.
View Article and Find Full Text PDFStudy of Minor Chromophores in Biological Tissues by Diffuse Optical Spectroscopy (Review).
Sovrem Tekhnologii Med
March 2025
PhD, Head of the Department of Radiophysical Methods in Medicine; Head of the Laboratory of Biophotonics; A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, 46 Ulyanov St., Nizhny Novgorod, 603950.
Diffuse optical spectroscopy (DOS) is a rapidly advancing non-invasive diagnostic technique to investigate biological tissue, based on probing the target object with optical radiation in the visible and/or near-infrared wavelength range and detecting the diffusely scattered light from the tissue. The signals obtained through DOS provide extensive information about the biochemical composition of tissues due to the presence of light-absorbing compounds known as chromophores. To date, DOS is widely employed to detect major chromophores such as deoxygenated (Hb) and oxygenated (HbO) hemoglobin, water, lipids, and melanin.
View Article and Find Full Text PDFMigration of Regulatory T Cells to the Peritumor Microenvironment of Experimental Glioblastoma.
Sovrem Tekhnologii Med
March 2025
MD, PhD, Head of the Laboratory of Solid Tumor Immunotherapy; Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russia, 1, Bldg. 10, Ostrovityanova St., Moscow, 117513, Russia; Senior Researcher, Laboratory of Cell Technologies; Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the Federal Medical Biological Agency of Russia, 28 Orekhovy Blvd., Moscow, 115682, Russia; Senior Researcher, Laboratory of Molecular Regeneration Mechanisms; Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow, 119991, Russia.
Unlabelled: Glioblastoma is the most aggressive primary brain tumor with poor prognosis characterized by resistance to standard treatments and immune evasion. Regulatory T lymphocytes (Tregs) play a key role in immune suppression in the tumor microenvironment and can be used as targets for malignant gliomas therapy. is to study migration of Tregs to the tumor site in the process of dynamic glioblastoma growth on the transgenic C57Bl/6-FoxP3-eGFP mouse line.
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