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Intraoperative isotonic balanced versus hypotonic crystalloids on postoperative sodium homeostasis in small children undergoing major neurosurgery: a randomized controlled trial.
BMC Pediatr
March 2025
Department of Anesthesiology, Peking University First Hospital, Beijing, China.
Background: Whether intraoperative isotonic balanced maintenance fluid is associated with less variation in sodium homeostasis in small children undergoing major neurosurgery remains unknown.
Methods: Patients aged up to 6 years undergoing major neurosurgery were randomly assigned to receive either isotonic balanced solution (IB) or 0.2% hypotonic solution (H) as intraoperative maintenance fluid.
An Exploratory Study on the Relationship Between Idiopathic Epilepsy and Sleep in Dogs.
J Vet Intern Med
March 2025
Department of Clinical Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Background: The bidirectional relationship between epilepsy and sleep is well characterized in humans but has not been thoroughly explored in dogs.
Objective: Evaluate sleep differences between dogs with idiopathic epilepsy and healthy controls and determine associations among epilepsy characteristics, antiseizure medications (ASMs), and sleep.
Animals: Sixty-four dogs with idiopathic epilepsy and 64 non-epileptic control dogs matched by age, breed, and sex.
Effectiveness and safety of adjunctive cenobamate in people with focal-onset epilepsy: Interim results after 24-week observational period from the BLESS study.
Epilepsia
March 2025
IRCCS Neuromed, Pozzilli (IS), Italy.
Objective: Cenobamate is an antiseizure medication (ASM) with a dual mechanism of action that was recently approved for the treatment of focal seizures in adults. This analysis aimed to describe the outcomes at 12 and 24 weeks after starting cenobamate therapy in a real-world setting.
Methods: BLESS [NCT05859854] is an ongoing, observational, retrospective and prospective cohort study to evaluate the real-world effectiveness and safety of adjunctive cenobamate in adults with uncontrolled focal epilepsy.
Trigeminal nerve stimulation in drug-resistant epilepsy: A systematic review.
Clin Neurol Neurosurg
March 2025
Department of Neurosurgery, University of Rochester, Rochester, NY, USA. Electronic address:
Introduction: Trigeminal Nerve Stimulation (TNS) is a technique that may be useful to reduce seizure burden in drug-resistant epilepsy (DRE), but its efficacy is not well characterized. This study sought to understand the application of TNS in DRE by providing a comprehensive overview of the current use and efficacy of TNS for neuromodulation in DRE.
Methods: A systematic review examining the use of TNS for DRE was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
VDAC1 Inhibition Mitigates Inflammatory Status and Oxidative Stress in Epileptic Mice Treated with the Ketogenic Diet.
Neurochem Res
March 2025
Department of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Due to the pleiotropic effects of ketogenic diet (KD) on pathophysiology, including inflammation and oxidative stress, medical personnels have been intensively exploring the application of it in the management of epilepsy. Meanwhile, the voltage-dependent anion channel 1 (VDAC1) is believed to be involved in regulating inflammatory and oxidative stress processes. However, the correlation between KD and VDAC1 in epilepsy has not been elucidated.
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