These case reports describe the application of three-dimensional conformal radiotherapy for the treatment of extensive juvenile angiofibroma. The affected areas included the pterygomaxillary fossa, infratemporal fossa, orbit, middle cranial fossa and maxillary sinus. Three-dimensional conformal radiotherapy was used to deliver the tumor dose of 3800-4140 cGy. The radiation dose to the surrounding normal structures including the optic nerve, optic chiasm, spinal cord, parotid and brain was limited. The tumor showed an excellent clinical and radiological response in both patients. There was no appreciable late toxicity. In conclusion, three-dimensional conformal radiotherapy provides several advantages over conventional radiotherapy in the treatment of extensive juvenile angiofibroma.
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