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Pharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide.
Semin Perinatol
April 2016
Department of Pediatrics, University at Buffalo, Buffalo, NY.
Inhaled nitric oxide (iNO) is approved for use in persistent pulmonary hypertension of the newborn (PPHN) but does not lead to sustained improvement in oxygenation in one-third of patients with PPHN. Inhaled NO is less effective in the management of PPHN secondary to congenital diaphragmatic hernia (CDH), extreme prematurity, and bronchopulmonary dysplasia (BPD). Intravenous pulmonary vasodilators such as prostacyclin, alprostadil, sildenafil, and milrinone have been successfully used in PPHN resistant to iNO.
View Article and Find Full Text PDFPathogenesis and management of irritable bowel syndrome.
Trop Gastroenterol
August 2009
Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India.
The exact cause of irritable bowel syndrome (IBS) is not known. Multiple factors, like genetic, gut motility, visceral hypersensitivity, psychosocial factors and immune-mediated factors, are thought to contribute to the symptom complex of IBS. Till date an 'IBS gene' has not been defined, and there is a need for further studies.
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