The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO2 measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO2 measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-1-4615-0075-9_43 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Splenic T2 signal intensity loss on MRI is associated with disease burden in multiple myeloma.
Eur Radiol
November 2024
Department of Medicine V, Multiple Myeloma Section, University Hospital Heidelberg, Heidelberg, Germany.
Article Synopsis
- - The study investigates how changes in spleen signal on various MRI sequences relate to the amount of plasma cell infiltration in the bone marrow of multiple myeloma patients, aiming to find a possible indicator for disease severity.
- - Researchers analyzed 45 newly diagnosed MM patients using whole-body MRI and found that spleen signal intensity negatively correlated with bone marrow plasma cell infiltration, meaning higher infiltration resulted in lower spleen signal.
- - Results suggest a significant association between spleen signal intensity, particularly on T2-weighted images, and tumor burden, providing potential insights for assessing disease in multiple myeloma patients.
Tailored polysaccharide entrapping metal-organic framework for RNAi therapeutics and diagnostics in atherosclerosis.
Bioact Mater
January 2025
Department of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen (UMCG), University of Groningen, Ant. Deusinglaan 1, 9713 AV, Groningen, the Netherlands.
Article Synopsis
- Metal-organic frameworks (MOFs) are being explored as carriers for treating atherosclerosis, but creating more complex and effective versions usually requires complicated synthesis.
- This study introduces a straightforward method to create a multifunctional platform using a specially designed polymer that can trap different MOFs while boosting their stability and targeting capabilities for macrophages involved in atherosclerosis.
- Testing showed that this platform significantly improved MRI signal intensity and effectively reduced plaque area by 43% through the targeted delivery of therapeutic agents, demonstrating its potential for treating atherosclerosis and possibly other similar conditions.
Quality of skeletal muscles during allogeneic stem-cell transplantation: a pilot study.
BMJ Support Palliat Care
October 2024
Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
Objectives: This study investigated the muscle fat fraction (FF) and muscle-related parameters before and after allogeneic hematopoietic stem cell transplantation (HSCT).
Methods: Fat and water signals were derived from the in-phase and out-of-phase MR signal intensities of the pelvis and thigh using the two-point Dixon technique. They were analysed using Synapse Vincent, and muscle quality was evaluated using the FF.
characterization of brain tumor biomechanics: magnetic resonance elastography in intracranial B16 melanoma and GL261 glioma mouse models.
Front Oncol
September 2024
Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.
Introduction: Magnetic Resonance Elastography (MRE) allows the non-invasive quantification of tumor biomechanical properties . With increasing incidence of brain metastases, there is a notable absence of appropriate preclinical models to investigate their biomechanical characteristics. Therefore, the purpose of this work was to assess the biomechanical characteristics of B16 melanoma brain metastases (MBM) and compare it to murine GL261 glioblastoma (GBM) model using multifrequency MRE with tomoelastography post processing.
View Article and Find Full Text PDFUltra-low-field magnetic resonance angiography at 0.05 T: A preliminary study.
NMR Biomed
November 2024
Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
We aim to explore the feasibility of head and neck time-of-flight (TOF) magnetic resonance angiography (MRA) at ultra-low-field (ULF). TOF MRA was conducted on a highly simplified 0.05 T MRI scanner with no radiofrequency (RF) and magnetic shielding.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!