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Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities.
Basic Res Cardiol
October 2024
Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Multiple common cardiovascular comorbidities produce coronary microvascular dysfunction. We previously observed in swine that a combination of diabetes mellitus (DM), high fat diet (HFD) and chronic kidney disease (CKD) induced systemic inflammation, increased oxidative stress and produced coronary endothelial dysfunction, altering control of coronary microvascular tone via loss of NO bioavailability, which was associated with an increase in circulating endothelin (ET). In the present study, we tested the hypotheses that (1) ROS scavenging and (2) ET-receptor blockade improve myocardial oxygen delivery in the same female swine model.
View Article and Find Full Text PDFEndothelin-converting Enzyme-1b Genetic Variants Increase the Risk of Coronary Artery Ectasia.
Biochem Genet
April 2024
Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Coronary artery ectasia (CAE), defined as a 1.5-fold or greater enlargement of a coronary artery segment compared to the adjacent normal coronary artery, is frequently associated with atherosclerotic coronary artery disease (CAD). Membrane-bound endothelin converting enzyme-1 (ECE-1) is involved in the maturation process of the most potent vasoconstrictor ET-1.
View Article and Find Full Text PDFAim: To evaluate the contribution of traditional and additional cardiovascular risk factors (CVRFs) to the development of chronic ischemic heart disease (CIHD) in liver transplant recipients during the long-term postoperative period.
Material And Methods: A single-center prospective cohort study was conducted. The study included 740 patients with chronic end-stage liver disease (CESLD) and cirrhotic cardiomyopathy (CCMP).
Identification of EDNRA as the Key Biomarker for Hypercholesterolemia and Colorectal Cancer.
Tohoku J Exp Med
March 2024
Department of Oncology, Maoming People's Hospital.
Some studies have investigated the role of cholesterol in the progression of colorectal cancer (CRC). However, the underlying mechanism of action is not clear. In this study, we used bioinformatics tools to elucidate the molecular mechanisms involved.
View Article and Find Full Text PDFWax apple ( ) fruit extract ameliorates endothelial dysfunction and liver damage in high cholesterol diet-fed rats.
J Tradit Complement Med
November 2022
Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Background And Aim: Wax apple fruit () is one of the most popular tropical fruit in Asia, and contains several essential nutrients. Therefore, this study explored the effects of the wax apple fruit extract on a high-cholesterol diet-induced vascular endothelial dysfunction and fatty liver in rats.
Experimental Procedure: Male Sprague Dawley rats were fed a diet with 1.
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