Three compounds, 2,3-dihydroxy-4-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran (1), 8-methoxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-6-ol (2) and 4-methoxy-3-(3-methyl-2-butenyl)-benzoic acid (3), have been isolated from Wigandia urens. The structures of compounds 1, 2 and 3 were determined from spectroscopic data and showed activity in a CCR5 assay with IC(50) values of 33, 46 and 26 muM respectively.
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Ecotoxicological effects of heavy metal bioaccumulation in two trophic levels.
Environ Sci Pollut Res Int
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Centro de Investigación en Biodiversidad y Conservación, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, C.P. 62209, Cuernavaca, Morelos, México.
The pollution generated by the heavy metals (HM) contained in mining wastes (tailings) is a worldwide recognized environmental concern. Due to the persistence, toxicity, bioaccumulation, and biomagnification capacity through the food chains, the release of HM into the environment causes negative effects on human health and the ecosystems. Wigandia urens Kunth (Boraginaceae) is a plant species that naturally establishes and grows in tailings and is consumed by the grasshopper Sphenarium purpurascens Charpentier (Orthoptera: Pyrgomorphidae).
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Ann Bot
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Instituto de Ecología, Universidad Nacional Autónoma de México, Apartado Postal 70-275, Ciudad Universitaria 04510, México, DF México.
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MerLion Pharmaceuticals, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore 118240.
Three compounds, 2,3-dihydroxy-4-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran (1), 8-methoxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-6-ol (2) and 4-methoxy-3-(3-methyl-2-butenyl)-benzoic acid (3), have been isolated from Wigandia urens. The structures of compounds 1, 2 and 3 were determined from spectroscopic data and showed activity in a CCR5 assay with IC(50) values of 33, 46 and 26 muM respectively.
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