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Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki. | LitMetric
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Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki.

Mun-Chual Rho Mi Yeon Chung Hye Young Song Oh Eok Kwon Seung Woong Lee Jin Ah Baek Kyung Hee Jeune Koanhoi Kim Hyun Sun Lee Young Kook Kim

Arch Pharm Res

Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.

Published: September 2003

In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 microg/mL.

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 Source
http://dx.doi.org/10.1007/BF02976679DOI Listing

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