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Nanocapsuled Neutrophil Extracellular Trap Scavenger Combating Chronic Infectious Bone Destruction Diseases.
Adv Sci (Weinh)
January 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Chronic infectious bone destruction diseases, such as periodontitis, pose a significant global health challenge. Repairing the bone loss caused by these chronic infections remains challenging. In addition to pathogen removal, regulating host immunity is imperative.
View Article and Find Full Text PDFMolecular mechanisms of regulation of IL-1 and its receptors.
Cytokine Growth Factor Rev
December 2024
Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology" (RIFCI), Novosibirsk 630099, Russia; Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. Electronic address:
Interleukin 1 (IL-1) is a pro-inflammatory cytokine that plays a key role in the development and regulation of nonspecific defense and specific immunity. However, its regulatory influence extends beyond inflammation and impacts a range of immune and non-immune processes. The involvement of IL-1 in numerous biological processes, including modulation of inflammation, necessitates strict regulation at multiple levels.
View Article and Find Full Text PDFRealization of reproductive qualities of cows and productivity of young stock.
Braz J Biol
September 2024
Candidate of Sciences in Agriculture, Director, "Scientific and Production Centre for Animal Husbandry and Veterinary" LLP, Astana, the Republic of Kazakhstan.
Article Synopsis
- A new biologic treatment, Prevention-N-A, was tested for calves and shown to be effective compared to the older PS-2 preparation, significantly reducing gynecological issues in pregnant cows.
- Three injections of the biologics improved reproductive health, decreased complications post-calving, and allowed for earlier heat cycles and better fertility rates.
- In calves, the treatment also boosted growth and development, leading to heavier weights and fewer illnesses compared to untreated peers.
[Factors of the hemostasis system as biomarkers of severe course of acute viral infections].
Zh Nevrol Psikhiatr Im S S Korsakova
March 2024
Pediatric Research and Clinical Center for Infectious Diseases, St. Petersburg, Russia.
The authors give literature review of hemostasis and immune system factors intraction as main biomarkers of a severe cause of viral infectious diseases. Pro-inflamatory cytokines as the main markers of inflammation, can serve both as biomarkers of the clinical severity of the infectious process and reflect the state of the hemostatic and fibrinolytic systems, since components of these systems are present in various structures of the central nervous system and affect the development of neurons and synaptic plasticity. An inverse correlation has been proven between the concentration of D-dimer and the oxygenation index, and the development of DIC is not associated with the presence of respiratory failure in patients with influenza type A, while the ferritin concentration directly reflects the severity of the disease.
View Article and Find Full Text PDFObjective: The aim: Evaluate the expediency of using different methods of treatment for patients with acute purulent-odontogenic inflammatory processes in both the main and control groups. This assessment will be based on various indicators of non-specific immunity.
Patients And Methods: Materials and methods: This study involved the evaluation of the humoral component of nonspecific immunity in 114 patients.
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