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Beyond the Usual Suspects: Appendiceal Bleeding as the Surprising Cause of Lower Gastrointestinal (GI) Bleeding.
Cureus
December 2024
Department of Surgery, Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, GBR.
Lower gastrointestinal bleeding (LGIB) is a common clinical condition typically associated with diseases like diverticular disease, inflammatory bowel disease, and cancer. However, rarer etiologies such as appendiceal hemorrhage can present similarly, complicating diagnosis and management. This case report discusses a 42-year-old male who presented with severe rectal bleeding.
View Article and Find Full Text PDFPriming from within: TLR2 dependent but receptor independent activation of the mammary macrophage inflammasome by Streptococcus uberis.
Front Cell Infect Microbiol
October 2024
School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom.
Introduction: is a member of the pyogenic cluster of commonly associated with intramammary infection and mastitis in dairy cattle. It is a poorly controlled globally endemic pathogen responsible for a significant cause of the disease worldwide. The ruminant mammary gland provides an atypical body niche in which immune cell surveillance occurs on both sides of the epithelial tissue.
View Article and Find Full Text PDFConstitutive, Muscle-Specific Knockout Results in the Incomplete Assembly of Ca Entry Units and a Reduction in the Age-Dependent Formation of Tubular Aggregates.
Biomedicines
July 2024
Center for Advanced Studies and Technology (CAST), University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.
Article Synopsis
- - Store-operated calcium entry (SOCE) is a critical process in cells that helps them maintain calcium levels, especially when internal stores are low, and occurs in specialized regions of skeletal muscle where specific proteins are located.
- - Mutations in certain proteins associated with SOCE are linked to a muscle disorder known as tubular aggregate myopathy, which shows an increase in specific structures as muscles age, particularly in male mice.
- - A study on mice with a muscle-specific knockout of a protein called Orai1 found that these mice had a shorter lifespan, reduced weight, exercise intolerance, and more damaged mitochondria, while also showing changes in muscle structure, including a lack of tubular aggregates with age.
Frequency and outcomes of gastrostomy insertion in a longitudinal cohort study of atypical parkinsonism.
Eur J Neurol
June 2024
Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, UK.
Background: Multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) show a high prevalence and rapid progression of dysphagia, which is associated with reduced survival. Despite this, the evidence base for gastrostomy is poor, and the optimal frequency and outcomes of this intervention are not known. We aimed to characterise the prevalence and outcomes of gastrostomy in patients with these three atypical parkinsonian disorders.
View Article and Find Full Text PDFPostapproval Study of a Subcutaneous Implantable Cardioverter-Defibrillator System.
J Am Coll Cardiol
August 2023
Mount Sinai Medical Center, Miami Beach, Florida, USA.
Background: The subcutaneous implantable cardioverter-defibrillator (S-ICD) was developed to avoid complications related to transvenous implantable cardioverter-defibrillator (TV-ICD) leads. Device safety and efficacy were demonstrated previously with atypical clinical patients or limited follow-up.
Objectives: The S-ICD PAS (Subcutaneous Implantable Cardioverter-Defibrillator System Post Approval Study) is a real-world, multicenter, registry of U.
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