AI Article Synopsis
- The study aimed to explore the link between idiopathic recurrent miscarriage and a specific gene polymorphism related to angiogenesis during pregnancy.
- The research involved comparing 131 women with a history of recurrent miscarriages to 125 healthy controls, using genetic analysis techniques.
- Ultimately, the findings revealed no significant association between the genetic polymorphism and the occurrence of recurrent miscarriages in the studied population.
Article Abstract
Objective: To investigate the relationship between idiopathic recurrent miscarriage and a polymorphism of the gene encoding for angiopoietin-2 (ANGPT2), an autochthonous modulator of angiogenesis during pregnancy.
Design: Prospective case control study.
Setting: Academic research institution.
Patient(s): One hundred thirty-one women with a history of three or more consecutive pregnancy losses before 20 weeks' gestation, and 125 healthy, postmenopausal controls with at least two live births and no history of pregnancy loss.
Intervention(s): Peripheral venous puncture.
Main Outcome Measure(s): Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the different ANGPT2 alleles.
Result(s): No association between mutant (mt) allele and the occurrence of idiopathic recurrent miscarriage was found. Between women with primary and secondary idiopathic recurrent miscarriage, no statistically significant differences with respect to allele frequencies were observed.
Conclusion(s): This is the first report on the ANGPT2 gene polymorphism in women with idiopathic recurrent miscarriage, demonstrating that the investigated polymorphism is not associated with idiopathic recurrent miscarriage in a white population.
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| http://dx.doi.org/10.1016/s0015-0282(03)01011-2 | DOI Listing |
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