Polymeric membrane electrodes for selective determination of methiaden.

Polyvinyl chloride matrix membrane ion-selective electrodes for the determination of methiaden hydrochloride based on the ion-pair of methiaden cation with tetraphenylborate anion were prepared using bis(2-ethylhexyl)sebacate, (electrode A), 2-nitrophenyl octyl ether (electrode B). 2-nitrophenyl dodecyl ether (electrode C) and 1-isopropyl-4-nitrobenzene (electrode D) as the membrane solvents. The electrodes exhibit near-Nernstian response in different concentration ranges, depending on the used membrane solvents. The basic analytical parameters of these electrodes were evaluated. The potentiometric titration method was used to determine methiaden hydrochloride with good precision and accuracy.