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Mitochondria-targeted antioxidant MitoQ radiosensitizes tumors by decreasing mitochondrial oxygen consumption.
Cell Death Discov
December 2024
Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium.
Hypoxic tumors are radioresistant stemming from the fact that oxygen promotes reactive oxygen species (ROS) propagation after water radiolysis and stabilizes irradiation-induced DNA damage. Therefore, an attractive strategy to radiosensitize solid tumors is to increase tumor oxygenation at the time of irradiation, ideally above a partial pressure of 10 mm-Hg at which full radiosensitization can be reached. Historically, the many attempts to increase vascular O delivery have had limited efficacy, but mathematical models predicted that inhibiting cancer cell respiration would be more effective.
View Article and Find Full Text PDFSuccessful Amendment of an Existing Hepatitis B Screening Programme by a Guideline Recommended Hepatitis D Screening in the Primary Care Setting.
Aliment Pharmacol Ther
December 2024
Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
Background: Despite European guidelines recommending anti-hepatitis D virus (HDV) screening for all hepatitis B surface antigen (HBsAg)-positive cases, screening rates remain insufficient.
Aims: We analysed anti-HDV screening rates in primary care and implemented prospective HDV screening in HBsAg-positive cases identified in the preventive medical examination from the age of 35 ("Check-Up 35+").
Methods: From 2012 to 2021, we reviewed anti-HDV and HDV RNA test rates in HBsAg-positive patients at 11 sites of a large German laboratory group.
[Genetic diseases with skin fragility in children].
Dermatologie (Heidelb)
December 2024
Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.
Article Synopsis
- Genetic diseases that cause skin fragility are diverse in their symptoms and genetic causes, making it crucial for healthcare professionals to differentiate them from more common conditions like infections or burns.
- The classification of these rare diseases is guided by their clinical presentation, histological characteristics, and genetic mutations, with most treatments being symptomatic rather than curative.
- Advances in genetic testing have integrated the study of these rare diseases into everyday clinical practice, emphasizing the need for collaboration among specialists to ensure proper diagnosis and care for affected children.
[Impact of various rehabilitation programs on anxiety and depression after surgery of early-stage cervical cancer].
Vopr Kurortol Fizioter Lech Fiz Kult
November 2024
S.S. Yudin City Clinical Hospital, Moscow, Russia.
Article Synopsis
- Cervical cancer (CC) is increasingly common and presents significant health care challenges, even with HPV vaccination and screening efforts; there's a need to understand rehabilitation's role in reducing anxiety and depression post-surgery.
- A study involving 103 female CC patients compared two rehabilitation programs: one multicomponent and the other adhering to standard guidelines, assessing anxiety and depression levels pre-surgery and over 36 months post-op using the Hospital Anxiety and Depression Scale (HADS).
- Results showed that the multicomponent rehabilitation significantly decreased anxiety and depression more effectively than the standard program, highlighting its importance in recovery for early-stage CC patients.
Cohesin complex oligomerization maintains end-tethering at DNA double-strand breaks.
Nat Cell Biol
October 2024
UMR Stabilité Génétique Cellules Souches et Radiations, Université Paris Cité, INSERM, CEA, Fontenay-aux-Roses, France.
DNA double-strand breaks (DSBs) must be repaired to ensure genome stability. Crucially, DSB-ends must be kept together for timely repair. In Saccharomyces cerevisiae, two pathways mediate DSB end-tethering.
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