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Pulmonary granuloma formation during latent infection in C3HeB/FeJ mice involves progression through three immunological phases.
mBio
January 2025
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
is a fungal pathogen that can cause lethal disease in immunocompromised patients. Immunocompetent host immune responses, such as formation of pulmonary granulomas, control the infection and prevent disseminated disease. Little is known about the immunological conditions establishing the latent infection granuloma in the lungs.
View Article and Find Full Text PDFDiagnosis of disseminated cryptococcosis via iliac bone marrow aspirate analysis.
IDCases
December 2024
Clinical Laboratory, Department of Clinical Laboratory, Shenzhen Longhua District People's Hospital, Shenzhen, PR China.
HIV infection frequently affects multiple systems, with hematological manifestations being the most prevalent. In some cases, cryptococcosis serves as the initial manifestation and a cause of infection involving HIV-positive patients. This case report describes a patient with thrombocytopenia who incidentally discovered infiltrating the bone marrow upon bone marrow smear examination, highlighting that examining bone marrow is essential in diagnosing pancytopenia resulting from opportunistic fungal infections like cryptococcosis, especially in individuals with compromised immune systems.
View Article and Find Full Text PDFEfficacy of two novel antifungal lipopeptides, AF and AF of bacillomycin D family in murine models of invasive candidiasis, cryptococcosis, and aspergillosis.
APMIS
January 2025
Department of Biological Sciences, BITS Pilani K.K. Birla Goa Campus, Zuari Nagar, Goa, India.
Invasive fungal diseases are an important public health concern due to an increase in the at-risk population and high mortality associated with these infections. Managing invasive fungal infections poses a significant challenge given the limited antifungal options and the emergence of resistance in key fungal pathogens. Through a comprehensive approach, we evaluated the in vitro antifungal activity and the in vivo efficacy of two novel lipopeptides, AF and AF in murine models of disseminated candidiasis, cryptococcosis, and aspergillosis.
View Article and Find Full Text PDFDisseminated Cryptococcal Gattii infection in a patient with anti-granulocyte-macrophage colony-stimulating-factor autoantibody: a case report.
BMC Infect Dis
December 2024
Division of Cardiovascular Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Background: Cryptococcosis is an opportunistic fungal infection in immunocompromised patients. The major species include Cryptococcus grubii, Cryptococcus neoformans, and rarely, Cryptococcus gattii. Here we present a disseminated Cryptococcus gattii infection in a patient with elevated granulocyte-macrophage colony-stimulating-factor autoantibody which was successfully treated with antifungal therapy.
View Article and Find Full Text PDFIL-22 and IL-23 regulate the anticryptococcal response during infection.
iScience
October 2024
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-900, Brazil.
Article Synopsis
- Cryptococcosis, caused by environmental fungi, leads to severe pneumonia and systemic infections, especially in immune-compromised individuals, with rising cases seen in immunocompetent hosts due to strain R265.* -
- The study investigates the roles of cytokines IL-22 and IL-23 in managing lung health during R265 infections, revealing their importance in preserving lung barrier integrity and preventing excessive damage.* -
- Findings indicate that IL-22 helps control neutrophil activity and promotes eosinophil presence in the lungs, providing crucial insights into immune response and tissue management during aggressive cryptococcal infections.*
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