Disorders or persistent noxious stimulation of the neuroimmunological circuitry can lead to neoplastic, neurological, immunological, psychiatric, or multiorgan pathology. The cause/effect relationship has encouraged a search for neuroimmunological markers possessing functional or pathological correlates. Among the molecules studied, those associated with the biopterin biosynthetic pathway (including neopterin) have proven to be useful and informative. This review addresses the relevance of the latter mediators to our understanding of the pathophysiology of neoplastic, neurological, psychiatric, and immunological disease processes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1615/jenvpathtoxoncol.v22.i2.50 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification of TAP2 as a novel immune target in human cancers: insights from integrated bioinformatics and experimental approaches.
Eur J Med Res
March 2025
The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Background: Transporter 2, ATP binding cassette (ABC) subfamily B member (TAP2), encodes a protein within the ABC transporter superfamily. TAP2 plays a role in the progression of cancers, such as cervical, breast, and lung cancers. However, the relationship between TAP2 and cancer prognosis, immune cell infiltration, tumor microenvironment, and immunotherapy remains unexplored.
View Article and Find Full Text PDFSpatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples.
Sci Adv
March 2025
Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Glioblastoma (GBM) is the most prevalent malignant brain tumor with poor prognosis. Although chromatin intratumoral heterogeneity is a characteristic feature of GBM, most current studies are conducted at a single tumor site. To investigate the GBM-specific 3D genome organization and its heterogeneity, we conducted Hi-C experiments in 21 GBM samples from nine patients, along with three normal brain samples.
View Article and Find Full Text PDFPseudobulbar affect: clinical associations, social impact and quality of life implications - Lessons from PLS.
J Neurol
March 2025
Computational Neuroimaging Group (CNG), School of Medicine, Trinity College, Pearse Street, Dublin, Ireland.
Background: Pseudobulbar affect (PBA) is a well-recognised and troublesome clinical phenomenon in a range of neuroinflammatory, neoplastic, neurovascular and neurodegenerative conditions. It is often under-recognised in the community, frequently mistaken for psychiatric manifestations, appropriate pharmacological treatment is often delayed, and may result in a sense of embarrassment or lead to social isolation. Despite its considerable quality of life (QoL) implications and the challenges associated with its effective management, it is notoriously understudied.
View Article and Find Full Text PDFLaser ablation of a fourth ventricular hamartoma causing medically refractory hemifacial spasms in a child: illustrative case.
J Neurosurg Case Lessons
March 2025
Division of Pediatric Neurosurgery, Department of Neurosurgery, University of Utah, Primary Children's Hospital, Salt Lake City, Utah.
Background: Hamartomas of the floor of the fourth ventricle (HFFVs) are rare lesions that cause a variety of symptoms, including hemifacial spasm (HFS). When symptomatic, these deep-seated lesions are traditionally treated via open surgical approaches. The authors describe successful laser interstitial thermal therapy (LITT) of an HFFV causing intractable HFS.
View Article and Find Full Text PDFCircular RNAs (circRNAs) are endogenous non-coding RNA molecules that form covalently closed molecular loops. By regulating gene expression, circRNAs are known to play crucial roles in the development and progression of various diseases, including autoimmune, neoplastic, and neurological disorders. In this study, we examined the expression of circSnx5 in inflamed CNS tissue at different stages of experimental autoimmune encephalitis (EAE), an animal model for multiple sclerosis (MS), as well as in T cells that were activated and differentiated into different T helper phenotypes (Th1, Th17, Treg).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!