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Fibrin-Based Hydrogels with Reactive Amphiphilic Copolymers for Mechanical Adjustments Allow for Capillary Formation in 2D and 3D Environments.
Gels
March 2024
Helmholtz Institute for Biomedical Engineering, BioInterface Group, RWTH Aachen University, Pauwelsstrasse 20, 52074 Aachen, Germany.
This study focuses on enhancing controllable fibrin-based hydrogels for tissue engineering, addressing existing weaknesses. By integrating a novel copolymer, we improved the foundation for cell-based angiogenesis with adaptable structural features. Tissue engineering often faces challenges like waste disposal and nutrient supply beyond the 200 µm diffusion limit.
View Article and Find Full Text PDFA chemo-mechano-biological modeling framework for cartilage evolving in health, disease, injury, and treatment.
Comput Methods Programs Biomed
April 2023
Department of Mechanical Engineering, University of Connecticut, Storrs, CT, USA; Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA. Electronic address:
Background And Objective: Osteoarthritis (OA) is a pervasive and debilitating disease, wherein degeneration of cartilage features prominently. Despite extensive research, we do not yet understand the cause or progression of OA. Studies show biochemical, mechanical, and biological factors affect cartilage health.
View Article and Find Full Text PDFHigh-Throughput Assay for Identifying Diverse Antagonists of the Binding Interaction between the ACE2 Receptor and the Dynamic Spike Proteins of SARS-CoV-2.
ACS Infect Dis
November 2022
Targeted Therapeutic Drug Discovery and Development Program, The University of Texas at Austin, Austin, Texas 78712, United States.
Article Synopsis
- SARS-CoV-2, the virus responsible for the COVID-19 pandemic, binds to human cells through its spike protein interacting with the ACE2 receptor; blocking this interaction is key to preventing infection.
- Researchers optimized an AlphaLISA assay to study the binding of the SARS-CoV-2 spike protein (S-614G variant) to ACE2 and screened over 30,000 compounds for potential inhibitors.
- Two effective compounds, oleic acid and suramin, were found to inhibit the interaction between S-614G and ACE2, with oleic acid showing stronger effects, highlighting the importance of using the full-length spike protein for identifying binding inhibitors.
Structure of the Ebola virus polymerase complex.
Nature
October 2022
CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Filoviruses, including Ebola virus, pose an increasing threat to the public health. Although two therapeutic monoclonal antibodies have been approved to treat the Ebola virus disease, there are no approved broadly reactive drugs to control diverse filovirus infection. Filovirus has a large polymerase (L) protein and the cofactor viral protein 35 (VP35), which constitute the basic functional unit responsible for virus genome RNA synthesis.
View Article and Find Full Text PDFMechanical Disturbance of Osteoclasts Induces ATP Release That Leads to Protein Synthesis in Skeletal Muscle through an Akt-mTOR Signaling Pathway.
Int J Mol Sci
August 2022
Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.
Muscle and bone are tightly integrated through mechanical and biochemical signals. Osteoclasts are cells mostly related to pathological bone loss; however, they also start physiological bone remodeling. Therefore, osteoclast signals released during bone remodeling could improve both bone and skeletal muscle mass.
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