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[Immunotherapy for Extensive-stage Small Cell Lung Cancer: Research Progress and Future Perspectives].
Zhongguo Fei Ai Za Zhi
November 2024
The Second Department of Thoracic Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.
At present, immunotherapy combined with chemotherapy has become the first-line standard of treatment for extensive-stage small cell lung cancer (ES-SCLC). In recent years, immune checkpoint inhibitors (ICIs) have received extensive attention and research in the field of lung cancer. At the same time, there are many challenges and tests in this process, such as the exploration of biomarkers, the exploration of new targets and new models, and the management of special populations.
View Article and Find Full Text PDFThe Management of Postpartum Cardiorespiratory Failure in a Patient with COVID-19 and Sickle Cell Trait Requiring Extraorporeal Membrane Oxygenation Support and Airflight Transportation.
J Clin Med
January 2025
Department of Cardiovascular & Thoracic Anaesthesia and Critical Care, University Hospital of Martinique, F-97200 Fort-de-France, Martinique, France.
Acute cardiovascular disorders are incriminated in up to 33% of maternal deaths, and the presence of sickle cell anemia (SCA) aggravates the risk of peripartum complications. Herein, we present a 24-year-old Caribbean woman with known SCA who developed a vaso-occlusive crisis at 36 weeks of gestation that required emergency Cesarean section. In the early postpartum period, she experienced fever with rapid onset of acute respiratory distress in the context of COVID-19 infection that required tracheal intubation and mechanical ventilatory support with broad-spectrum antibiotics and blood exchange transfusion.
View Article and Find Full Text PDFResilient Privacy Preservation Through a Presumed Secrecy Mechanism for Mobility and Localization in Intelligent Transportation Systems.
Sensors (Basel)
December 2024
Institute for Production Technology and Systems (IPTS), Leuphana Universität Lüneburg, 21335 Lüneburg, Germany.
An intelligent transportation system (ITS) offers commercial and personal movement through the smart city (SC) communication paradigms with hassle-free information sharing. ITS designs and architectures have improved via information and communication technologies in recent years. The information shared through the communication medium in SCs is exposed to adversary risk, resulting in privacy issues.
View Article and Find Full Text PDFChallenges and Prospects of Sensing Technology for the Promotion of Tele-Physiotherapy: A Narrative Review.
Sensors (Basel)
December 2024
Department of Physical Therapy, Graduate School of Health Science, Juntendo University, Tokyo 113-0033, Japan.
Significant developments in sensing technology have had many impacts, enhancing monitoring and assessment accuracy across diverse fields. In the field of physical therapy, sensing, which plays a pivotal role in tele-physiotherapy, rapidly expanded amid the COVID-19 pandemic. Its primary objective is to monitor biological signals and patient movements at remote locations.
View Article and Find Full Text PDFIdentification of the EBF1/ETS2/KLF2-miR-126-Gene Feed-Forward Loop in Breast Carcinogenesis and Stemness.
Int J Mol Sci
January 2025
Department of Experimental Medicine, Tor Vergata University of Rome, 00133 Rome, Italy.
MicroRNA (miR)-126 is frequently downregulated in malignancies, including breast cancer (BC). Despite its tumor-suppressive role, the mechanisms underlying miR-126 deregulation in BC remain elusive. Through silencing experiments, we identified Early B Cell Factor 1 (EBF1), ETS Proto-Oncogene 2 (ETS2), and Krüppel-Like Factor 2 (KLF2) as pivotal regulators of miR-126 expression.
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