Objective: This study assessed a new self-etch/priming system for use in orthodontic bonding.
Setting: An ex vivo study.
Method: Three groups of 20 extracted premolar teeth were bonded with metal orthodontic brackets. Group 1 was bonded with Transbond using the conventional technique (control). Group 2 was bonded using the new Transbond-Plus combined etch/primer system to wet enamel and Group 3 to dry enamel. The teeth were debonded using an Instron Universal Testing Machine. The mean debond force was calculated for each group and compared statistically. The teeth were examined under the stereomicroscope to assess the site of debond and adhesive remnant index.
Results: Group 2 (etch/primer on wet enamel) had the lowest mean debond value at 5.2 MPa. ANOVA and Tukey tests confirmed that the bond strength results of Group 2 were significantly lower than Groups 1 (P < 0.01) and 3 (P < 0.05). The enamel/resin interface was the commonest site of bond failure for both etch/primer groups (Groups 2 and 3). They had less retained resin and significantly (P < 0.001) lower ARI scores compared with Group 1 (control).
Conclusions: The results of this ex vivo study suggest that the self-etch primer should achieve adequate bond strengths when applied to dry enamel surfaces. In addition there should be less retained resin requiring removal at debond.
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http://dx.doi.org/10.1093/ortho/30.3.225 | DOI Listing |
Proc Natl Acad Sci U S A
February 2025
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
The ionizable lipid component of lipid nanoparticle (LNP) formulations is essential for mRNA delivery by facilitating endosomal escape. Conventionally, these lipids are synthesized through complex, multistep chemical processes that are both time-consuming and require significant engineering. Furthermore, the development of new ionizable lipids is hindered by a limited understanding of the structure-activity relationships essential for effective mRNA delivery.
View Article and Find Full Text PDFHeliyon
January 2025
Division of Polymer Chemistry, Department of Chemistry, Atomic Energy Commission, P.O. Box: 6091, Damascus, Syrian Arab Republic.
The degree of sulfonation (DS) is a key property of sulfonated polymers, as it significantly influences their swelling behaviour, conductivity and mechanical properties. Accurately determining the DS is essential for optimizing these materials for various applications. In this work, the DS of sulfonated poly (ether ether ketone) (SPEEK) was evaluated using a combination of analytical techniques, including titration, back titration, Fourier Transform Infrared (FTIR), Ultra-Violet (UV) and proton nuclear magnetic resonance (H NMR) spectroscopies, Thermogravimetric analysis (TGA), Rutherford backscattering (RBS) and particle induced X-ray emission (PIXE) analysis.
View Article and Find Full Text PDFR Soc Open Sci
January 2025
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK.
Chronic myeloid leukaemia (CML) is primarily treated using imatinib mesylate, a tyrosine kinase inhibitor (TKI) targeting the BCR::ABL1 oncoprotein. However, the development of drug resistance and adverse side effects necessitate the exploration of alternative therapeutic agents. This study presents the synthesis and characterization of a novel imatinib analogue, 3-chloro--(2-methyl-5-((4-(pyridin-2-yl)pyrimidin-2-yl)amino)phenyl)benzamide (PAPP1).
View Article and Find Full Text PDFMed Sci Monit
January 2025
College of Dentistry, King Khalid University, Abha, Saudi Arabia.
BACKGROUND Indirect ceramic restorations often need multiple firings to match the shade of natural teeth or need after-correction and ceramic addition during the clinical trial stage. Many studies have examined how multiple firings affect the mechanical characteristics of zirconia-veneered prostheses. The effect of firing number on adhesion between these core and heat-pressed lithium disilicate veneering ceramics is unclear.
View Article and Find Full Text PDFSci Rep
January 2025
Conservative Dentistry Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
This study aimed to compare the bonding efficacy three bioactive self-adhesive restorative systems to dentin. A total of 80 permanent human molars were utilized in this study. The occlusal enamel was removed to exposed mid-coronal dentin; 40 molars were used for microshear bond strength testing, while the remaining molars were used for micromorphological analysis of restoration/dentin interface.
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