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The functional role of oscillatory dynamics in neocortical circuits: A computational perspective.
Proc Natl Acad Sci U S A
January 2025
Ernst Strüngmann Institute, Frankfurt am Main 60528, Germany.
The dynamics of neuronal systems are characterized by hallmark features such as oscillations and synchrony. However, it has remained unclear whether these characteristics are epiphenomena or are exploited for computation. Due to the challenge of selectively interfering with oscillatory network dynamics in neuronal systems, we simulated recurrent networks of damped harmonic oscillators in which oscillatory activity is enforced in each node, a choice well supported by experimental findings.
View Article and Find Full Text PDFBio-Inspired Highly Stretchable and Ultrafast Autonomous Self-Healing Supramolecular Hydrogel for Multifunctional Durable Self-Powered Wearable Devices.
Small
January 2025
Institute of Biomass and Function Materials & National Demonstration Centre for Experimental Light Chemistry Engineering Education, College of Bioresources Chemistry and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, P. R. China.
As skin bioelectronics advances, hydrogel wearable devices have broadened perspectives in environment sensing and health monitoring. However, their application is severely hampered by poor mechanical and self-healing properties, environmental sensitivity, and limited sensory functions. Herein, inspired by the hierarchical structure and unique cross-linking mechanism of hagfish slime, a self-powered supramolecular hydrogel is hereby reported, featuring high stretchability (>2800% strain), ultrafast autonomous self-healing capabilities (electrical healing time: 0.
View Article and Find Full Text PDFComprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis.
Orthop Surg
January 2025
Department of Orthopedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin, China.
Objective: Knee osteoarthritis (KOA) is characterized by structural changes. Aging is a major risk factor for KOA. Therefore, the objective of this study was to examine the role of genes related to aging and circadian rhythms in KOA.
View Article and Find Full Text PDFAssessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues.
J Pathol
January 2025
The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Spatial transcriptomics (ST) offers enormous potential to decipher the biological and pathological heterogeneity in precious archival cancer tissues. Traditionally, these tissues have rarely been used and only examined at a low throughput, most commonly by histopathological staining. ST adds thousands of times as many molecular features to histopathological images, but critical technical issues and limitations require more assessment of how ST performs on fixed archival tissues.
View Article and Find Full Text PDFSe-methylselenocysteine inhibits inflammatory response in an LPS-stimulated chicken HD11 macrophage-like cell model through the NFKB2 pathway.
Front Vet Sci
January 2025
College of Animal Science and Technology, Yangtze University, Jingzhou, China.
Among the various sources of selenium supplementations, the Se-methylselenocysteine (SeMC) is a natural organic selenium compound that has been demonstrated to have multiple advantages in terms of metabolism efficiency and biosafety in animals. Nevertheless, the genome-wide impact of SeMC on gene transcription remains to be elucidated. In this study, we employed an LPS-stimulated chicken HD11 macrophage-like cell model to identify the principal transcription factors involved in transcriptome regulation responsible for SeMC treatment.
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