Clinical mass spectrometry in neuroscience. Proteomics and peptidomics.

Cell Mol Biol (Noisy-le-grand)

Institute of Clinical Neuroscience, Experimental Neuroscience Section, Göteborg University, Sweden.

Published: July 2003

In this review we discuss the merits and drawbacks with the use of proteomic and peptidomic strategies for identification of proteins and peptides in their multidimensional interactions in complex biological processes. The progress in proteomics and peptidomics during the last years offer us new challenges to study changes in the protein and peptide synthesis. These strategies also offer new tools to follow post-translational modifications and other disturbed chemical processes that may be indicative of pathophysiological alteration(s). Furthermore these techniques can contribute to improvements in the diagnosis and therapy of neurodegenerative diseases, such as Alzheimer's disease, and psychiatric diseases, as depression and post traumatic stress disorders. We also consider different practical aspects of the applications of mass spectrometry in clinical neuroscience, illustrated by example from our laboratories. The new proteomic and peptidomic strategies will further enable the progress for clinical neuroscience research.

Download full-text PDF

Source

Publication Analysis

Top Keywords

mass spectrometry
8
proteomics peptidomics
8
proteomic peptidomic
8
peptidomic strategies
8
clinical neuroscience
8
clinical mass
4
spectrometry neuroscience
4
neuroscience proteomics
4
peptidomics review
4
review discuss
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!