Plasma aldosterone concentrations were measured by radioimmunoassay and metabolic clearance rates (M.C.R.) were determined by a continuous infusion of H3-aldosterone on day 20 and 50 and at 3, 6 and 24 months in the male and the female guinea-pig. Plasma aldosterone concentration rose gradually from day 20 up to 24 months. At every stage the values were always higher in the female than in the male. M.C.R. (1/24 h/100 g) decreased from day 20 to 24 months and appeared to be sex-dependent in the guinea-pig.
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