AI Article Synopsis
- The study focuses on the unusual occurrence of renal cell carcinoma (RCC) metastasizing to the pancreas, where selective pancreatic resection can be beneficial for some patients.
- A review of 14 patients who had both nephrectomy for RCC and pancreatic resections revealed that most had solitary metastases and a significant time interval from nephrectomy to pancreatic diagnosis.
- Results indicated that half of the patients showed no signs of disease at a median follow-up of 32 months, suggesting that pancreatic resection can lead to long-term survival in selected RCC cases.
Article Abstract
Background: The diverse natural history of renal cell carcinoma (RCC) includes metastases to the pancreas, a very unusual site for distant spread of other cancers. Considering the relatively indolent behavior of some cases of metastatic RCC, pancreatic resection is offered to select patients.
Methods: We reviewed the records of patients at three affiliated university hospital centers who had prior nephrectomy for RCC and subsequent pancreatic resection of metastases.
Results: Fourteen patients--9 women and 5 men with a median age of 63.8 years--underwent a total of 15 pancreatic resections for metastatic RCC. Nine (64%) had solitary metastases. The median interval from nephrectomy to diagnosis of pancreatic metastases was 83 months. The median size of metastases was 4.6 cm. There was one perioperative death. Pancreatic recurrence occurred in five patients (36%), and one patient underwent repeat resection. At a median follow-up of 32 months, seven patients (50%) are alive without evidence of disease, and four patients (28%) are alive with recurrent disease.
Conclusions: Resection of pancreatic metastases from RCC is associated with long-term survival and should be considered for patients in whom complete resection is possible.
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| http://dx.doi.org/10.1245/aso.2003.02.003 | DOI Listing |
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