Distal femoral cortical irregularity (DFCI) is a benign entity presenting with either an irregular appearance or a focal radiolucency within the posterior cortex of the distal femur. Atypical cases should be differentiated from malignant lesions. The typical location of the lesion at the attachment of the head of the medial gastrocnemius muscle can be visualised using different imaging techniques. We report a case of a DFCI in a 13-year old boy. The diagnosis was based on CT-imaging. Two years later, no radiological abnormalities could be observed. A review of the literature is presented.
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Unfallchirurgie (Heidelb)
January 2025
Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsmedizin Rostock, Schillingallee 35, 18057, Rostock, Deutschland.
Background: Given that a primary osteoporotic fracture can result in subsequent fractures and that the precise etiology of the typical fracture cascade remains uncertain, it is pertinent to determine the initiating factor and the specific fracture involved in this cascade.
Method: All patients with a fracture of a long bone were consecutively screened over the 12-month study period. All participants were asked about existing risk factors (including previous fractures) in accordance with the applicable guidelines of the Umbrella Organization Osteology (DVO).
J Cachexia Sarcopenia Muscle
February 2025
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Background: Anti-Activin Receptor Type IIA and Type IIB antibody (αActRIIA/IIB ab) is a recently developed drug class that targets the activin receptor signalling pathway. Inhibition of receptor ligands (activins, myostatin, growth differentiation factor 11, etc.) can lead to skeletal muscle hypertrophy, bone formation, and increased haematopoiesis.
View Article and Find Full Text PDFAnn Anat
January 2025
Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria; Teaching Center, Medical University of Vienna, Vienna, Austria.
Background: The intercondylar space is defined as the topographic area walled by the intercondylar notch (IN) and encasing the central ligaments of the knee joint. As the anterior cruciate ligament (ACL) is not only impinged against the roof but also against the lateral wall of the IN, information concerning changes to the IN during the progression of osteoarthritis could be potentially relevant in predicting the future risk for ACL-rupture and -degeneration and ensure preventive measures as early as possible. Therefore, the purpose of this study was to evaluate the influence of osteoarthritis on osseous notch morphology.
View Article and Find Full Text PDFJ Endocrinol
January 2025
U Iwaniec, Skeletal Biology Laboratory, Oregon State University, Corvallis, United States.
Leptin increases focal inflammation and osteolysis induced by polyethylene particles in leptin-deficient ob/ob mice suggesting the adipokine, an important immune modulator, contributes to orthopedic implant failure. Focal inflammation leads to bone loss at distant skeletal sites, and it is plausible that leptin also contributes to this response. We tested this possibility in 6-week-old female ob/ob mice (6-8/group) by evaluating bone architecture, turnover, and gene expression 12 days following surgical placement of polyethylene particles over calvaria.
View Article and Find Full Text PDFCalcif Tissue Int
January 2025
University of Pittsburgh, 3860 S. Water St., Pittsburgh, PA, 15203, USA.
Sport participation affects body composition and bone health, but the association between sport, body composition, and bone health in female athletes is complex. We compared areal bone mineral density (aBMD, DXA) and tibial volumetric bone mineral density (vBMD), geometry, microarchitecture, and estimated strength (HR-pQCT) in cross-country runners (n = 22), gymnasts (n = 23) and lacrosse players (n = 35), and investigated associations of total body lean mass (TBLM), team, and their interaction with tibial bone outcomes. Total body (TB), total hip (TH), femoral neck (FN), and lumbar spine (LS) aBMD were higher in gymnasts than runners (p < 0.
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